1352731-59-9Relevant articles and documents
Design, synthesis, and application of tartaric acid derived N-spiro quaternary ammonium salts as chiral phase-transfer catalysts
Waser, Mario,Gratzer, Katharina,Herchl, Richard,Mueller, Norbert
, p. 251 - 254 (2012/02/06)
A novel class of tartaric acid-derived N-spiro quaternary ammonium salts was synthesised starting from known TADDOLs. These compounds were found to catalyse the asymmetric α-alkylation of glycine Schiff bases with high enantioselectivities and in good yie
Investigations concerning the syntheses of TADDOL-derived secondary amines and their use to access novel chiral organocatalysts
Gratzer, Katharina,Waser, Mario
, p. 3661 - 3670 (2013/02/22)
A structurally carefully diversified library of novel TADDOL-derived chiral secondary amines was synthesized and investigated for their applicability to obtain new organocatalysts like chiral Lewis bases and chiral phase-transfer catalysts. The scope and limitations of the developed syntheses routes to access these catalysts as well their catalytic performance in different benchmark reactions were systematically investigated. The most powerful of the catalysts prepared was found to be highly useful for the phase-transfer catalyzed α-alkylation of glycine Schiff base (high yields and up to 93% ee). Georg Thieme Verlag KG Stuttgart · New York.