Chiral synthetic equivalents of 2-cyanoethyl tetraisopropylphosphorodiamidite: Application to the synthesis and resolution of chiral phosphoric acids
Four synthetic equivalents of (iPr2N)2P-OCH 2CH2CN (1) have been prepared from readily available enantiomerically pure β-hydroxynitriles as well as from chiral β-hydroxy esters. To demonstrate their possible use