Total synthesis of milbemycins: A synthesis of (6R)-6-hydroxy-3,4- dihydromilbemycin E
Following studies using benzyloxymethyl isopropenyl ketone 5 and ethyl 3-(3-furyl)-3-oxopropanoate 6, Robinson reactions between aryloxymethyl isopropenyl ketones 19 and 5 and ethyl 3-(2-trimethylsilyl-3-furyl)-3- oxopropanoate 20 were found to be stereos
Helliwell, Madeleine,Karim, Sufia,Parmee, Emma R.,Thomas, Eric J.
p. 3636 - 3653
(2007/10/03)
Milbemycin synthesis: Synthesis of 6β-hydroxy-3,4-dihydromilbemycin E
The hydroxycyclohexanone (7) is readily available via a Robinson annelation, and is converted into the hydroxybutenolide (15) which is incorporated into a synthesis of 6β-hydroxy-3,4-dihydromilbemycin E (28).
Karim, Sufia,Parmee, Emma R.,Thomas, Eric J.
p. 2269 - 2272
(2007/10/02)
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