SYNTHESIS OF N--ACETOHYDROXAMIC ACIDS, POTENTIAL INHIBITORS OF THE 5-LIPOXYGENASE
The synthesis of the title compounds starts from methyl (3-subst.phenoxy)alkanoates II which are reduced to the corresponding aldehydes and then transformed to oximes V by reaction with hydroxylamine.Reduction with borane-pyridine complex gives the hydroxylamines VI which on diacetylation and partial deacetylation provide the hydroxamic acids VIII.
Svoboda, Jiri,Palecek, Jaroslav
p. 1317 - 1332
(2007/10/02)
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