Novel 3-methylindoline inhibitors of EZH2: Design, synthesis and SAR
EZH2 (enhancer of zeste homologue 2) is the catalytic subunit of the polycomb repressive complex 2 (PRC2) that catalyzes the methylation of lysine 27 of histone H3 (H3K27). Dysregulation of EZH2 activity is associated with several human cancers and theref
Ansari, Amantullah,Satalkar, Sharad,Patil, Varshavekumar,Shete, Amit S.,Kaur, Simranjeet,Gupta, Ashu,Singh, Siddhartha,Raja, Mohd.,Severance, Daniel L.,Bernales, Sebastián,Chakravarty, Sarvajit,Hung, David T.,Pham, Son M.,Herrera, Francisco J.,Rai, Roopa