- Ir-Catalyzed Enantioconvergent Synthesis of Diversely Protected Allenylic Amines Employing Ammonia Surrogates
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The first iridium catalyzed, enantioconvergent amination of allenylic carbonates is reported. This process utilizes various commercially available carbamates and sulfonamides to generate allenylic amines including commonly employed protected groups (Boc, Fmoc, Cbz, Ts, Ns) in 62–82 % yield and 87–98 % ee. The products generated through this scalable procedure serve as effective linchpins for the rapid, enantiospecific synthesis of a wide range of complex structures.
- Carreira, Erick M.,Glatz, Fabian,Petrone, David A.
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- A catalytic asymmetric borono variant of Hosomi-Sakurai reactions with N,O-aminals
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Aminal attraction: The combination of indium(I) chloride and a chiral silver binol phosphate provides an excellent catalyst for asymmetric Hosomi-Sakurai reactions between N,O-aminals and boronates (see scheme; PG=protecting group, pin=pinacolato). The su
- Huang, Yi-Yong,Chakrabarti, Ananya,Morita, Naohide,Schneider, Uwe,Kobayashi, Sha
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supporting information; experimental part
p. 11121 - 11124
(2012/02/02)
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