135380-53-9

Basic information

• Product Name: 2,7-DIAZASPIRO[4.4]NONANE, 2-METHYL-
• Synonyms: 2,7-DIAZASPIRO[4.4]NONANE, 2-METHYL-;2-METHYL-2,7-DIAZASPIRO[4.4]NONANE;2,7-Diazaspiro[4.4]nonane, 2-Methyl- (or 2-Methyl-2,7-diazaspiro[4.4]nonane)
• CAS NO: 135380-53-9
• Molecular Formula: C₈H₁₆N₂
• Molecular Weight: 140.23
• Mol File: 135380-53-9.mol

Chemical Properties

• Boiling Point: 181.677 °C at 760 mmHg
• Flash Point: 62.603 °C
• Appearance: /
• Density: 1.015 g/cm³
• Vapor Pressure: 0.842mmHg at 25°C
• Refractive Index: 1.528
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2,7-DIAZASPIRO[4.4]NONANE, 2-METHYL-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,7-DIAZASPIRO[4.4]NONANE, 2-METHYL-(135380-53-9)
• EPA Substance Registry System: 2,7-DIAZASPIRO[4.4]NONANE, 2-METHYL-(135380-53-9)

Safety Data

• Hazardous Substances Data: 135380-53-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,7-Diazaspiro[4.4]nonane, 2-methylis utilized as a key intermediate in organic synthesis for the preparation of heterocyclic compounds, which are vital in the development of pharmaceuticals with novel therapeutic properties.
Used in Drug Discovery:
2,7-Diazaspiro[4.4]nonane, 2-methylserves as a lead compound in drug discovery, given its potential to contribute to the creation of new therapeutic agents with unique mechanisms of action and applications in treating various diseases.
Used in Medicinal Chemistry Research:
2,7-Diazaspiro[4.4]nonane, 2-methylis employed in medicinal chemistry research to explore its biological activity and to understand its interactions with biological targets, which can provide insights into the design of more effective drugs.

InChI:InChI=1/C8H16N2/c1-10-5-3-8(7-10)2-4-9-6-8/h9H,2-7H2,1H3

Upstream product

• 91189-24-1 2-methyl-2,7-diazaspiro<4.4>nonane-1,3,8-trione 
• 91189-23-0 ethyl 3-(ethoxycarbonyl)-5-oxo-3-pyrrolidineacetate 
• 91189-26-3 2-methyl-7-(phenylmethyl)-2,7-diazaspiro[4.4]nonane dihydrochloride 

Relevant articles and documents

Synthesis and differential functionalisation of pyrrolidine and piperidine based spirodiamine scaffolds

The synthesis and differential substitution/protection of a series of spirodiamine scaffolds are described. Methods for selective access to the two mono-N-methyl isomers based on 2,7-diazaspiro[4.5]decane are also described. Key precursors associated with this chemistry are prone to rearrangement and methods for circumventing this issue are reported. While direct mono-carbamoylation (Boc) was not efficient, selective deprotection of doubly Boc-protected derivatives derived from symmetrical diamines provided mono-Boc variants. N-Arylation, exemplified by a series of monosubstituted spirodiamines incorporating the 2-chloro-5-pyridyl moiety, which is a privileged nicotinic agonist substructure, has also been carried out to provide monoarylated secondary and tertiary spirodiamines variants.

Quinolone Antibacterial Agents Substituted at the 7-Position with Spiroamines. Synthesis and Structure-Activity Relationships

A series of fluoroquinolone antibacterials having the 7-position (10-position of pyridobenzoxazines) substituted with 2,7-diazaspirononane (4b), 1,7-diazaspirononane (5a), or 2,8-diazaspiroundecane (6b) was prepared, and their biological activities were compared with piperazine and pyrrolidine substituted analogues.Most exhibited potent Gram-positive and Gram-negative activity, especially when side chain 4b was N-alkylated.