Synthesis and Antifolate Evaluation of the 10-Propargyl Derivatives of 5-Deazafolic Acid, 5-Deazaaminopterin, and 5-Methyl-5-deazaaminopterin
5-Deaza-10-propargylfolic acid (4), an analogue of the thymidylate synthase (TS) inhibitor 10-propargyl-5,8-dideazafolic acid (PDDF, 1), was prepared via alkylation of diethyl N--L-glutamate (7) by 2-amino-6-(bromomethyl)-4(3H)-
Piper, J. R.,Malik, N. D.,Rhee, M. S.,Galivan, J.,Sirotnak, F. M.
p. 332 - 337
(2007/10/02)
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