- I2-mediated oxidative C-N bond formation for metal-free one-pot synthesis of di-, tri-, and tetrasubstituted pyrazoles from α,β-unsaturated aldehydes/ketones and hydrazines
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An I2-mediated metal-free oxidative C-N bond formation methodology has been established for the regioselective pyrazole synthesis. This practical and eco-friendly one-pot protocol requires no isolation of the less stable intermediates hydrazone
- Zhang, Xinting,Kang, Jinfeng,Niu, Pengfei,Wu, Jie,Yu, Wenquan,Chang, Junbiao
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p. 10170 - 10178
(2015/02/19)
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- Palladium-catalyzed dehydrogenative β-arylation of simple saturated carbonyls by aryl halides
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(Chemical Equation Presented) A versatile palladium-catalyzed synthesis of highly substituted α,β-unsaturated carbonyl compounds has been developed. In contrast to the known Heck-type coupling reaction of unsaturated carbonyl compounds with aryl halides, the present methodology allows the use of stable and readily available saturated carbonyl compounds as the alkene source. In addition, the reaction proceeds well with low catalyst loadings and does not require any expensive metal oxidants or ligands. A variety of saturated aldehydes, ketones, and esters are compatible for the reaction with aryl halides under the developed reaction conditions to afford α,β-unsaturated carbonyl compounds in good to excellent yields. A possible reaction mechanism involves a palladium-catalyzed dehydrogenation followed by Heck-type cross couplings.
- Gandeepan, Parthasarathy,Rajamalli,Cheng, Chien-Hong
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p. 4485 - 4489
(2015/01/09)
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- Practical metal-free synthesis of chalcone derivatives via a tandem cross-dehydrogenative-coupling/elimination reaction
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Metal-free synthesis of chalcone derivatives through a tandem cross-dehydrogenative-coupling/elimination reaction is described. A simple and inexpensive ammonium persulfate salt enables the reaction between ketones and benzylamines to proceed with high stereoselectivity and good functional group compatibility.
- Wei, Yu,Tang, Jinghua,Cong, Xuefeng,Zeng, Xiaoming
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supporting information
p. 3165 - 3169
(2013/11/06)
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- Ytterbium triflate promoted coupling reaction between aryl alkynes and aldehydes
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A simple and efficient solvent-free coupling reaction affording regioselectively trans-α,β-enones from aryl alkynes and aldehydes catalysed by Yb(OTf)3 hydrate is described.
- Curini, Massimo,Epifano, Francesco,Maltese, Federica,Rosati, Ornelio
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p. 552 - 554
(2007/10/03)
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- PREPARATION OF 1-PHENYL-3-METHYLISOQUINOLINE AND ITS DERIVATIVES FROM OXIMES OF 3-ARYL-2-METHYL-1-PHENYL-2-PROPEN-1-ONES
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1-Phenyl-3-methylisoquinoline and its derivatives substituted in 5, 6 or 7 positions (4) have been obtained by cyclization reaction of N-α-methylstyrylbenzimidoyl chloride (3) produced by Beckmann rearrangement by appopriate oximes (2) in the presence of PCl5.
- Zielinski, Wojciech
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p. 2209 - 2215
(2007/10/02)
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