- Synthetic method of 1,2-diketone compound
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The invention discloses a synthetic method of a 1,2-diketone compound. The method comprises the following steps: under room temperature, an alkyne compound is taken as a raw material, a Ru/C is takenas a catalyst, an oxidizing agent and sulfuric acid are added, acetonitrile and water with a volume ratio being 1-5:1 are taken as solvents, the materials are completely reacted at the temperature of20-30 DEG C, and a reaction solution is subjected to separating and purifying to obtain the 1,2-diketone compound. The method has the advantages that operation is simple, reaction time is short, yield(achieving to 100%) is high, substrate universality is wide, water and acetonitrile are taken as the primary solvents (the solvent acetonitrile is easily recovered and used), and a heterogeneous phase catalyst Ru/C is easily recovered. The synthetic method of the 1,2-diketone compound accords with green chemistry characteristic, and is very suitable for industrialization.
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Paragraph 0041-0044
(2018/06/14)
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- An unusual chemoselective oxidation strategy by an unprecedented exploration of an electrophilic center of DMSO: A new facet to classical DMSO oxidation
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A conceptually new dimethyl sulfoxide (DMSO) based oxidation process without the use of any activator has been demonstrated for the oxidation of active methylenes and benzhydrols. The developed protocol utilizes the electrophilic center of DMSO for oxidation, which was unexplored before. Mechanistic investigation has confirmed that the source of oxygen is DMSO.
- Chebolu, Rajesh,Bahuguna, Ashish,Sharma, Reena,Mishra, Vivek Kumar,Ravikumar
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p. 15438 - 15441
(2015/10/20)
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- Cobalt(II) catalyzed C(sp)-H bond functionalization of alkynes with phenyl hydrazines: Facile access to diaryl 1,2-diketones
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A cobalt acetylacetonate catalyzed oxidative diketonation of alkynes via C(sp)-H bond functionalization has been described. The reaction involves a free-radical mechanism, wherein the phenyl radical formed from phenyl hydrazine couples with Co(ii) activated alkyne to produce 1,2-diketones. The reaction proceeds at room temperature in DMF with the use of Ag2O/air as the oxidizing system. The utility of the protocol for the synthesis of a series of imidazoles including a potent platelet aggregation inhibitor trifenagrel has been demonstrated.
- Bharate, Jaideep B.,Abbat, Sheenu,Sharma, Rohit,Bharatam, Prasad V.,Vishwakarma, Ram A.,Bharate, Sandip B.
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p. 5235 - 5242
(2015/05/13)
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- THE REACTION OF SOME SUBSTITUTED BENZILS AND HETEROCYCLIC ANALOGS WITH CHLOROSULFONIC ACID
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The chlorosulfonation of a number of unsymmetrical benzils gave substituted benzofurans.Ring closure is dependent upon the electronic character of the substituent groups and can be controlled by electronwithdrawing groups.The reaction of the 2-thienyl ana
- Cremlyn, Richard J.,Lynch, John M.,Swinbourne, Frederick J.
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p. 173 - 179
(2007/10/02)
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