135525-78-9

Basic information

• Product Name: 3-(4,7-Dichlorobenzoxazol-2-ylmethylamino)-5-ethyl-6-methylpyridin-2(1H)-one
• Synonyms: L-697661; 3-{[(4,7-dichloro-1,3-benzoxazol-2-yl)methyl]amino}-5-ethyl-6-methylpyridin-2(1H)-one
• CAS NO: 135525-78-9
• Molecular Formula: C₁₆H₁₅Cl₂N₃O₂
• Molecular Weight: 352.2152
• Mol File: 135525-78-9.mol

Chemical Properties

• Boiling Point: 558.6°C at 760 mmHg
• Flash Point: 291.6°C
• Density: 1.41g/cm³
• Vapor Pressure: 1.65E-12mmHg at 25°C
• Refractive Index: 1.649
• CAS DataBase Reference: 3-(4,7-Dichlorobenzoxazol-2-ylmethylamino)-5-ethyl-6-methylpyridin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4,7-Dichlorobenzoxazol-2-ylmethylamino)-5-ethyl-6-methylpyridin-2(1H)-one(135525-78-9)
• EPA Substance Registry System: 3-(4,7-Dichlorobenzoxazol-2-ylmethylamino)-5-ethyl-6-methylpyridin-2(1H)-one(135525-78-9)

Safety Data

• Hazardous Substances Data: 135525-78-9(Hazardous Substances Data)

Usage

Molecular Structure

Includes a benzoxazolylmethylamino group and a pyridinone group

Synthesis

Achieved through multiple chemical reactions

Usage

Employed in research and pharmaceutical applications

Potential Medicinal Properties

May exhibit antimicrobial, antioxidant, or anti-inflammatory effects

Biological Activities

Under study for various therapeutic uses

Complex Structure Advantage

Potential for binding to specific biological targets

Drug Development

Promising candidate for pharmaceutical development

Applications in Research

Potential uses in chemical research and development of new materials

Upstream product

• 135397-32-9 3-amino-5-ethyl-6-methyl-pyridin-2(1H)-one 
• 135397-31-8 2-chloromethyl-4,7-dichloro-benzoxazole 
• 139549-61-4 4,7-dichloro-2-(iodomethyl)benzoxazole 
• 205653-35-6 2-chloromethyl-5-bromo-4,7-dichlorobenzoxazole 
• 107-87-9 2-Pentanone 
• 100868-47-1 2-amino-3,6-dichlorophenol 
• 3114-64-5 2,5-dichloro-6-nitrophenol 
• 37721-85-0 4-bromo-3,6-dichloro-2-nitrophenol 
• 205653-36-7 3-[(5-Bromo-4,7-dichloro-benzooxazol-2-ylmethyl)-amino]-5-ethyl-6-methyl-1H-pyridin-2-one 
• 143745-99-7 2-ethyl-3-oxobutanal sodium salt 
• 139393-81-0 5-ethyl-6-methyl-3-nitro-2(1H)-pyridinone 

Relevant articles and documents

The synthesis of several tritiated non-nucleoside, HIV-1 reverse transcriptase inhibitors

The synthesis of three tritiated reverse transcriptase inhibitors is described herein. These compounds contained the benzoxazole ring linked to a 2-pyridinone ring by an aminomethylene group. The tritiated compounds were synthesized by hydrogenolysis of bromobenzoxazole precursors. The final tritiated compounds had specific activities ranging from 3-10 Cl/mmol.

Synthesis and Evaluation of 2-Pyridinone Derivatives as HIV-1-Specific Reverse Transcriptase Inhibitors. 2. Analogues of 3-Aminopyridin-2(1H)-one

A series of nonnulceoside 3-aminopyridin-2(1H)-one derivatives was synthesized and evaluated for HIV-1 RT inhibitory properties.Several analogs proved to be potent and highly selective antagonists with in vitro IC50 values as low as 19 nM in the enzyme assay using rC*dG as template*primer.Two compounds from this series, 3-amino>-5-ethyl-6-methylpyridin-2(1H)-one (34, L-697,639) and the corresponding 4,7-dichloro analogue (37, L-697,661) inhibited the spread of HIV-1 IIIb infection by 95percent in MT4 cell culture at concentrations of 25-50 nM and were selected for clinical trials as antiviral agents.