135564-61-3

Basic information

• Product Name: 2-FLUORO-5-METHYLBENZOYL CHLORIDE
• Synonyms: 2-FLUORO-5-METHYLBENZOYL CHLORIDE;Benzoyl chloride, 2-fluoro-5-methyl- (9CI);2-Fluoro-5-Methylbenzoyl chlororide
• CAS NO: 135564-61-3
• Molecular Formula: C₈H₆ClFO
• Molecular Weight: 172.58
• Product Categories: Fluorine series;ACIDHALIDE;Aromatic Halides (substituted)
• Mol File: 135564-61-3.mol

Chemical Properties

• Boiling Point: 215.1°Cat760mmHg
• Flash Point: 83.9°C
• Appearance: /
• Density: 1.265g/cm³
• Vapor Pressure: 0.15mmHg at 25°C
• Refractive Index: 1.5335
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 2-FLUORO-5-METHYLBENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-5-METHYLBENZOYL CHLORIDE(135564-61-3)
• EPA Substance Registry System: 2-FLUORO-5-METHYLBENZOYL CHLORIDE(135564-61-3)

Safety Data

• RIDADR: UN3265
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 135564-61-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Fluoro-5-Methylbenzoyl Chloride is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications, making it a valuable component in the medicinal chemistry field.
Used in Chemical Synthesis:
In the chemical industry, 2-Fluoro-5-Methylbenzoyl Chloride is used as a versatile building block for the production of a wide range of chemical compounds. Its reactivity enables the formation of various derivatives, which can be further utilized in different applications, such as the creation of specialty chemicals, agrochemicals, and materials for research purposes.
Used in Research and Development:
2-Fluoro-5-Methylbenzoyl Chloride is employed as a research compound in academic and industrial laboratories. Its unique properties and reactivity make it an interesting subject for studying chemical reactions, exploring new synthetic routes, and developing novel applications in various fields, including materials science and biotechnology.

InChI:InChI=1/C8H6ClFO/c1-5-2-3-7(10)6(4-5)8(9)11/h2-4H,1H3

Upstream product

• 321-12-0 2-fluoro-5-methyl-benzoic acid 

Downstream Products

• 286434-72-8 N-(diphenyl-phosphinoylmethyl)-2-fluoro-5,N-dimethyl-benzamide 
• 1447827-59-9 5-((tert-butoxycarbonyl)amino)-2-(2-fluoro-5-methylphenyl)thiazole-4-carboxylic acid 
• 1586041-30-6 5-amino-N-(5-((2S,5R,6S)-5-amino-6-fluorooxepan-2-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2-fluoro-5-methylphenyl)thiazole-4-carboxamide 
• 1449291-16-0 C₁₁H₁₁FO₃ 
• 1439356-76-9 methyl 1,6-dimethyl-4-oxo-2-phenyl-1,4-dihydroquinoline-3-carboxylate 

Relevant articles and documents

Transition metal-free one-pot synthesis of 2-substituted 3-carboxy-4-quinolone and chromone derivatives

A novel one-pot synthesis of the 2-substituted 3-carboxy-4-quinolone/ chromone derivatives from readily available 3-oxo-3-arylpropanoates and amides/acyl chlorides is reported, without any transition metal aid. The Royal Society of Chemistry 2013.

N-substituted peptidyl nitriles as cysteine cathepsin inhibitors

Compounds of the formula (I), wherein R1 is aryl or biaryl; R2 is aryl-lower alkyl, biaryl-lower alkyl, benzo-fused cycloalkyl, cycloalkyl-lower alkyl, bicycloalkyl-lower alkyl, aryloxy-lower alkyl, or aryl-C2-C7/sub

A versatile synthesis of poly- and diversely substituted isoindolin-1- ones

A variety of diversely substituted isoindolin-1-ones have been prepared by alkaline cleavage of the C-P bond in the corresponding phosphorylated lactams obtained by base-induced aryne-mediated cyclization of o-halogeno-N- (phosphinylmethyl)benzamide derivatives.