- Imino Diels-Alder reactions: an efficient one-pot synthesis of pyrano and furanoquinoline derivatives catalyzed by SbCl3
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Antimony trichloride (SbCl3) was found to be an efficient catalyst for the inverse electron demand imino Diels-Alder reactions of in situ generated N-benzylidenes with 3,4-dihydro-2H-pyran and 2,3-dihydrofuran to afford pyrano and furano[3,2-c]quinolines in excellent yields.
- Maiti, Gourhari,Kundu, Pradip
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- Synthesis and antimicrobial evaluation of some 4-thiazolidinone derivatives containing polynuclear hydrocarbon
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Some 4-thiazolidinone derivatives have also been known to be associated with several biological activities thus can be utilized as promising scaffold for developing analogues. Aryl aldehydes were treated with naphthylamine to yield corresponding Schiff's
- Verma, Neelam,Singh, Raj Bhushan,Singh, Kuldeep
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Read Online
- Analgesic, anti-inflammatory activity and docking study of 2-(substituted phenyl)-3-(naphthalen-1-yl)thiazolidin-4-ones
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A potential analgesic and anti-inflammatory activities have been reported in 4-thiazolidinone analogs as well as some drugs bearing naphthyl moiety such as naproxen. Thus a reported series of 2-(substituted phenyl)-3-(naphthalen-1-yl)thiazolidin-4-ones (T
- Agrawal, Neetu,Upadhyay, Prabhat K.,Mujwar, Somdutt,Mishra, Pradeep
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- Analgesic, anti-inflammatory activity and docking study of 2-(substituted phenyl)-3-(naphthalen- 1-yl)thiazolidin-4-ones
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A potential analgesic and anti-inflammatory activities have been reported in 4-thiazolidinone analogs as well as some drugs bearing naphthyl moiety such as naproxen. Thus a reported series of 2-(substituted phenyl)-3-(naphthalen-1-yl)thiazolidin-4- ones (
- Agrawal, Neetu,Upadhyay, Prabhat K.,Mujwar, Somdutt,Mishra, Pradeep
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- Stereoselective Synthesis of 3-(5-Benzoyl-1-methyl-1 H -pyrrol-2-yl)-2-azetidinone Derivatives via an in Situ Generated Ketene
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A short route toward β-lactams from tolmetin has been developed. In the key step, a ketene was generated on the C-2 of pyrrole ring and reacted with aromatic imines to form trans -β-lactams as the only observed products. The identification of the ketene was confirmed by reaction with the stable free radical TEMPO (TO·).
- Bananezhad, Behjat,Islami, Mohammad Reza
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supporting information
p. 1453 - 1456
(2017/07/22)
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- Sustainable iron-catalyzed direct imine formation by acceptorless dehydrogenative coupling of alcohols with amines
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The Acceptorless Dehydrogenative Coupling (ADC) of alcohols with amines is reported using a heterogeneous Fe-catalyst. The reaction operates under mild conditions with the liberation of dihydrogen and water as the byproducts. The developed ADC strategy is simple, efficient, exhibits wide functional group tolerance and can be scaled up. The present catalytic approach possesses a dual role; acting as a catalyst as well as being magnetically separable. The sustainable reuse of a heterogeneous iron catalyst is also shown.
- Jaiswal, Garima,Landge, Vinod G.,Jagadeesan, Dinesh,Balaraman, Ekambaram
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supporting information
p. 3232 - 3238
(2016/06/15)
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- An efficient method for the synthesis of indolo[3,2-c]quinoline derivatives catalyzed by iodine
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The reaction of Schiff base and indole catalyzed by iodine in DMA, subsequently treated with DDQ, gave indolo[3,2-c]quinoline derivatives in good yields. The structure of 3e was confirmed by X-ray diffraction analysis. The reaction of Schiff base and indo
- Zhou, Yujing,Zhang, Meimei,Yin, Mingyue,Wang, Xiangshan
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p. 237 - 242
(2013/08/24)
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- Synthesis and antibacterial activities of some schiff bases
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Schiff bases p-hydroxybenzylidene-2-carboxyaniline, p-nitrobenzylidene-2- carboxyaniline, p-(N, N-dimethyl)aminobenzylidene-2-carboxyaniline, N-(4-hydroxybezylidene)-benzene-1,2-diamine, N-(4-nitrobezylidene)benzene-1,2- diamine,N-(4-(N, N-dimethylaminobezylidene)benzene-1,2-diamine, N-(4-(N,Ndimethylamino) benzylidene)naphthalen-1-amine,N-(4-nitrobenzylidene) naphthalen-1-amine,N-(4-chlorobenzylidene)naphthalen-1-amine,sodium-4-(4-(N, N-dimethyl amino)benzylideneamino)naphthalene-1-sulfonate,sodium -4-(4-nitrobenzylideneamino) naphthalene-1-sulfonate and sodium-4-(4- chlorobenzylideneamino) naphthalene-1-sulfonate obtained by condensation of aniline and naphthylamine derivatives with some aromatic aldehydes were characterized by physical and spectral methods. The biological activity of these products were as antibacterial agents against three species of human pathogenic bacteria such as Escherichia coli, Staphylococcus aureus and Klebsiella sp. Nearly 50% of these compounds showed reasonable activity against the bacterial species investigated and we found that the antibacterial activity is dependent on the molecular structure of the compounds.
- Ibrahim, Mohamed N.,Sharif, Salaheddin A. I.,El-Tajory, Ahmad N.,Elamari, Asma A.
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experimental part
p. 212 - 216
(2012/02/04)
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- Antileishmanial, antimicrobial and antifungal activities of some new aryl azomethines
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A series of eighteen azomethines has been synthesized by the reaction of appropriate primary aromatic amines with aryl and/or heteroaryl carboxaldehydes. The synthesized azomethines have been evaluated for their in vitro antileishmanial, antibacterial and antifungal activities. The results revealed some antifungal activity of most of the synthesized compounds, whereas the antileishmaniasis activity results highlighted that all synthesized azomethines inhibited parasite growth and most of them showed highly potent action towards Leishmania major promastigotes. No remarkable bactericidal activities were observed.
- Al-Kahraman, Yasser M.S.A.,Madkour, Hassan M.F.,Ali, Dildar,Yasinzai, Masoom
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experimental part
p. 660 - 671
(2010/06/16)
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- A thermal study of some Schiff bases derivative of α-napthylamine
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Thermal analyses of some Schiff bases, derivative of α-napthylamine, were performed by the DSC, TG and DTA techniques. The thermograms were used to determine various kinetic parameters, such as the order of degradation (n), energy of activation (E), frequ
- Baluja, Shipra,Pandya, Nirmal,Vekariya, Nayan
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experimental part
p. 1601 - 1604
(2009/02/03)
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- Quantitative solid-solid synthesis of azomethines
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Twenty preparatively useful azomethines have been quantitatively (100% yield at 100% conversion) obtained as hydrates by grinding together solid anilines with solid benzaldehydes without passing through liquid phases. Unlike (acid catalyzed) azomethine syntheses in solution, the solid-solid condensations proceed 'waste-free'. The solid-state mechanisms have been elucidated by atomic force microscopy (AFM) and in part by scanning near-field optical microscopy (SNOM) in three cases. The results indicate long distance migration of the aldehydes into the lattice of the aniline derivatives. Stumpy protrusions are formed at the direct points of contact but also distance sublimation (100 nm range) is succesful in the case of p-chlorobenzaldehyde and p-nitroaniline. Long-range flow of 4-hydroxybenzaldehyde molecules on its (010)-face into contracting crystals of p-toluidine or p-anisidine occurs along two different cleavage planes. Steep hills and valleys are left behind. The molecular migrations through the sites of contact are interpreted in terms of crystals packing. The ease of these solid-solid condensation reactions relies on the crystal packing.
- Schmeyers, Jens,Toda, Fumio,Boy, Juergen,Kaupp, Gerd
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p. 989 - 993
(2007/10/03)
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- Cycloaddition of (N-Alkyl-N-phenylamino)ketene with Imines
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(N-Alkyl-N-phenylamino)ketenes were prepared in the presence of various imines, and a cycloaddition reaction occurred to yield 3-(N-alkyl-N-phenylamino)-2-azetidinones.The size and electronic nature of the imine substituents were varied in order to probe those factors that influence the stereochemistry of the cycloaddition.The stereochemistry of the 2-azetidinone was determined by the substitution pattern of the imines.In general, the stereochemistry of the 2-azetidinone products are significantly influenced by the bulk of the N substituent on the imine.These results are discussed in terms of a two-step zwitterionic intermediate.
- Brady, William T.,Dad, Mohammad M.
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p. 6118 - 6122
(2007/10/02)
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