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CAS

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135575-42-7

Pneumocandin B0 is an antifungal lipopeptide that acts by inhibiting the synthesis of β-(1,3)-D-glucan, a component of fungal cell walls. It is the major analogue of a family of lipopeptides isolated from various species of different genera, such as Cryptosporiopsis, Glarea, and Pezicula. Pneumocandin B0 can be used to synthesize the echinocandin caspofungin acetate.

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  • 135575-42-7 Structure

  • Basic information

    1. Product Name: Pneumocandin B0
    2. Synonyms: Pneumocardin B0;pneumocandin B(0);B0 PneuMocandin B0;Caspofungin PneuMocandin B0 IMpurity;Caspofungin Intermediate;neumocandin B0;CFA;PneumocandinBo
    3. CAS NO:135575-42-7
    4. Molecular Formula: C50H80N8O17
    5. Molecular Weight: 1065.22
    6. EINECS: 1312995-182-4
    7. Product Categories: Antifungals;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;API;Other APIs
    8. Mol File: 135575-42-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 1442.936 °C at 760 mmHg
    3. Flash Point: 826.458 °C
    4. Appearance: /
    5. Density: 1.411 g/cm3
    6. Vapor Pressure: 0mmHg at 25°C
    7. Refractive Index: 1.629
    8. Storage Temp.: Sealed in dry,Store in freezer, under -20°C
    9. Solubility: DMSO (Slightly), Methanol (Sparingly)
    10. PKA: 9.86±0.26(Predicted)
    11. CAS DataBase Reference: Pneumocandin B0(CAS DataBase Reference)
    12. NIST Chemistry Reference: Pneumocandin B0(135575-42-7)
    13. EPA Substance Registry System: Pneumocandin B0(135575-42-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 135575-42-7(Hazardous Substances Data)

135575-42-7 Usage

Uses

Used in Pharmaceutical Industry:
Pneumocandin B0 is used as an antifungal agent for treating infections caused by susceptible fungi. It is particularly effective against Candida and Aspergillus species, which are common causes of fungal infections in humans.
Used in Drug Synthesis:
Pneumocandin B0 is used as the starting point for the synthesis of the antifungal drug caspofungin. Caspofungin is a semi-synthetic lipopeptide that has been developed for the treatment of invasive fungal infections, particularly those caused by Candida and Aspergillus species.
Used in Research and Development:
Pneumocandin B0 serves as a valuable compound in the research and development of new antifungal agents. Its unique mechanism of action and potent antifungal properties make it an important tool for studying the biology of fungal cell walls and the development of novel therapeutic strategies against fungal infections.

Check Digit Verification of cas no

The CAS Registry Mumber 135575-42-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,5,5,7 and 5 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 135575-42:
(8*1)+(7*3)+(6*5)+(5*5)+(4*7)+(3*5)+(2*4)+(1*2)=137
137 % 10 = 7
So 135575-42-7 is a valid CAS Registry Number.
InChI:InChI=1/C50H80N8O17/c1-5-25(2)20-26(3)12-10-8-6-7-9-11-13-37(66)52-31-22-35(64)46(71)56-48(73)41-33(62)18-19-57(41)50(75)39(34(63)23-36(51)65)54-47(72)40(43(68)42(67)28-14-16-29(60)17-15-28)55-45(70)32-21-30(61)24-58(32)49(74)38(27(4)59)53-44(31)69/h14-17,25-27,30-35,38-43,46,59-64,67-68,71H,5-13,18-24H2,1-4H3,(H2,51,65)(H,52,66)(H,53,69)(H,54,72)(H,55,70)(H,56,73)/t25?,26?,27-,30+,31-,32-,33-,34-,35+,38-,39-,40-,41-,42-,43-,46+/m0/s1

135575-42-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name Pneumocandin B0

1.2 Other means of identification

Product number -
Other names B0 PneuMocandin B0

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:135575-42-7 SDS

135575-42-7Upstream product

135575-42-7Related news

Antifungal lipopeptides: Structure-activity relationships of 3-hydroxyglutamine-modified Pneumocandin B0 (cas 135575-42-7) derivatives08/14/2019

Selective methanolysis or dehydration followed by reduction of the 3-hydroxyglutamine residue of pneumocandin B0 (1) or its dideoxy analog 5 (L-692,289) gave the methyl 3-hydroxyglutamate and 3-hydroxyornithine analogs 6 and 9, respectively. Further derivatization of these analogs allowed a stud...detailed

135575-42-7Relevant articles and documents

Stationary phases and a purification process using the stationary phases

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Page/Page column 7-8, (2008/06/13)

This invention relates to a novel stationary phase of Formula I and a method for purifying a peptide or lipopeptide in liquid chromatography using select stationary phases, including the stationary phases of Formula I to improve the resolution and/or productivity of the purification. This chromatographic method can be used for either an analytical or preparative scale purification.

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