- Sequential alkylation/cyclization/isomerization of ethyl 3-(o-trifluoroacetamidoaryl)-1-propargylic esters: A new route to 2-acyl- and 2-ethoxycarbonyl-3-alkenyl indoles
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The reaction of ethyl 3-(o-trifluoroacetamidoaryl)-1-propargylic esters with ethyl iodoacetate or α-bromoacetophenone in the presence of K 2CO3 in DMSO provides a new simple access to 2-acyl- and 2-ethoxycarbonyl-3-alkenyl indoles.
- Ambrogio, Ilaria,Arcadi, Antonio,Cacchi, Sandro,Fabrizi, Giancarlo,Goggiamani, Antonella,Marinelli, Fabio
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- Design of C3-Alkenyl-Substituted 2-Indolylmethanols for Catalytic Asymmetric Interrupted Nazarov-Type Cyclization
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The C3-alkenyl-substituted 2-indolylmethanols have been designed as a new class of substrates for catalytic asymmetric interrupted Nazarov-type cyclizations. In the presence of chiral phosphoric acid as a mild chiral Br?nsted acid, the interrupted Nazarov
- Wang, Cong-Shuai,Wu, Jia-Le,Li, Can,Li, Lin-Zhi,Mei, Guang-Jian,Shi, Feng
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supporting information
p. 846 - 851
(2018/03/06)
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- Synthesis of substituted indoles from 2-azidoacrylates and ortho-silyl aryltriflates
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2-Azidoacrylates react with benzynes in the presence of PPh3 and CsF to afford substituted indoles in good yields. The reaction involves the formation of iminophosphorane and benzyne and a subsequent double cyclization/hydrolysis/air-oxidation cascade. This methodology was utilized to synthesize 10H-indolo[1,2-a]indol-10-ones.
- Hong, Deng,Chen, Zhengbo,Lin, Xufeng,Wang, Yanguang
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supporting information; experimental part
p. 4608 - 4611
(2010/12/18)
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- HETEROCYCLIC RENIN INHIBITORS
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A renin inhibiting compound of the formula: STR1 wherein A is a substituent; R 1 is loweralkyl, loweralkenyl, alkoxyalkyl, [(alkoxy) alkoxy]alkyl, alkoxycarbonylalkyl, carboxyalkyl, (thioalkoxy) alkyl, benzyl or heterocyclic ring substituted methyl; R 2 i
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