- Conversion of nucleoside H-phosphonate monoesters to the corresponding H- phosphonothioates. 31P NMR studies
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31P NMR Studies on the conversion of nucleoside H-phosphonate monoesters into the corresponding H-phosphonothioates revealed that the key intermediate, the nucleoside trimethylsilyl pivaloyl phosphite 3, may undergo under the reaction condition
- Stawinski,Zain
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- Nucleoside H-phosphonates, XXII: Synthesis and properties of new nucleotide analogues - H-phosphonothiolate diesters
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Condensation of nucleoside 3′-H-phosphonate monoesters with various thiols, promoted by condensing agents, provides a convenient access to a new class of H-phosphonate analogues, H-phosphonothiolate diesters. Chemical properties, relevant to possible appl
- Hiresova, Renata,Stawinski, Jacek
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p. 2748 - 2752
(2008/03/14)
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- Aryl H-phosphonates. 6. Synthetic studies on the preparation of nucleoside N-alkyl-H-phosphonamidates
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Various approaches to the synthesis of nucleoside H-phosphonamidates have been investigated. Direct couplings of nucleoside H-phosphonates with amines have been hampered by extensive reactions of the condensing agents with amines. Preactivation of nucleos
- Sobkowska, Anna,Sobkowski, Michall,Cieslak, Jacek,Kraszewski, Adam,Kers, Inger,Stawinski, Jacek
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p. 4791 - 4794
(2007/10/03)
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- Nucleoside H-phosphonates. 15. Preparation of nucleoside H-phosphonothioate monoesters from the corresponding nucleoside H-phosphonates
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A convenient method for the preparation of nucleoside 3'-H-phosphonothioate monoesters from suitably protected nucleoside 3'-H-phosphonates has been developed. It consists of activation of nucleoside H-phosphonates with pivaloyl chloride in the presence of a limited amount of a base followed by treatment with 1,1,1,3,3,3-hexamethyldisilathiane (HMDST).
- Zain,Stromberg,Stawinski
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p. 8241 - 8244
(2007/10/03)
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