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N-(3-iodophenyl)maleimide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 135861-54-0 Structure
  • Basic information

    1. Product Name: N-(3-iodophenyl)maleimide
    2. Synonyms: N-(3-iodophenyl)maleimide
    3. CAS NO:135861-54-0
    4. Molecular Formula: C10H6 I N O2
    5. Molecular Weight: 299.06
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 135861-54-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 393.8°Cat760mmHg
    3. Flash Point: 191.9°C
    4. Appearance: /
    5. Density: 1.963g/cm3
    6. Vapor Pressure: 2.08E-06mmHg at 25°C
    7. Refractive Index: 1.705
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: N-(3-iodophenyl)maleimide(CAS DataBase Reference)
    11. NIST Chemistry Reference: N-(3-iodophenyl)maleimide(135861-54-0)
    12. EPA Substance Registry System: N-(3-iodophenyl)maleimide(135861-54-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 135861-54-0(Hazardous Substances Data)

135861-54-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 135861-54-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,5,8,6 and 1 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 135861-54:
(8*1)+(7*3)+(6*5)+(5*8)+(4*6)+(3*1)+(2*5)+(1*4)=140
140 % 10 = 0
So 135861-54-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H6INO2/c11-7-2-1-3-8(6-7)12-9(13)4-5-10(12)14/h1-6H

135861-54-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(3-iodophenyl)pyrrole-2,5-dione

1.2 Other means of identification

Product number -
Other names 1H-Pyrrole-2,5-dione,1-(3-iodophenyl)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:135861-54-0 SDS

135861-54-0Upstream product

135861-54-0Downstream Products

135861-54-0Relevant articles and documents

Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors

Matuszak, Nicolas,Muccioli, Giulio G.,Labar, Geoffray,Lambert, Didier M.

experimental part, p. 7410 - 7420 (2010/04/30)

The endocannabinoid 2-arachidonoylglycerol (2-AG) plays a major role in many physiological processes, and its action is quickly terminated via enzymatic hydrolysis catalyzed by monoglyceride lipase (MGL). Regulating its endogenous level could offer therapeutic opportunities; however, few selective MGL inhibitors have been described so far. Here, we describe the synthesis of N-substituted maleimides and their pharmacological evaluation on the recombinant human fatty acid amide hydrolase (FAAH) and on the purified human MGL. A few N-arylmaleimides were previously described (Saario, S. M.; Salo, O. M.; Nevalainen, T.; Poso, A.; Laitinen, J. T.; Jarvinen, T.; Niemi, R. Characterization of the Sulfhydryl-Sensitive Site in the Enzyme Responsible for Hydrolysis of 2-Arachidonoylglycerol in Rat Cerebellar Membranes. Chem. Biol. 2005, 12, 649-656) as MGL inhibitors, and along these lines, we present a new set of maleimide derivatives that showed low micromolar IC50 and high selectivity toward MGL vs FAAH. Then, structure-activity relationships have been investigated and, for instance, 1-biphenyl-4-ylmethylmaleimide inhibits MGL with an IC50 value of 790 nM. Furthermore, rapid dilution experiments reveal that these compounds act as irreversible inhibitors. In conclusion, N-substituted maleimides constitute a promising class of potent and selective MGL inhibitors.

Radiohalogenated half-antibodies and maleimide intermediate therefor

-

, (2008/06/13)

N-(m-radiohalophenyl) maleimide can be conjugated with a reduced antibody having a mercapto group to provide a radiolabelled half-antibody having immunological specific binding characteristics of whole antibody.

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