The Invention of Radical Reactions. XXXIII Homologation Reactions of Carboxylic Acids by Radical Chain Chemistry
Various carbon radicals can be generated from carboxylic acids via the corresponding Barton esters.These radicals can be used for the synthesis of longer chain homologues of the original acids.
Barton, Derek H. R.,Chern, Ching-Yuh,Jaszberenyi, Joseph Cs.
p. 407 - 426
(2007/10/02)
HOMOLOGATION OF ACIDS via CARBON RADICALS GENERATED FROM THE ACYL DERIVATIVES OF N-HYDROXY-2-THIOPYRIDONE. (THE TWO-CARBON PROBLEM).
Reaction of suitable substituted olefins with carbon radicals generated from the acyl derivatives of N-hydroxy-2-thiopyridone results in the formation of precursors for the corresponding homo-acids.These compounds can then be transformed to the desired end-products in high yield under mild conditions.
Barton, Derek H. R.,Chern, Ching-Yuh,Jaszberenyi, Joseph Cs.
p. 3309 - 3312
(2007/10/02)
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