- CRYSTALLINE S-(-)-AMLODIPINE MALEIC ACID SALT ANHYDRIDE AND PREPARATION METHOD THEREOF
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Disclosed are an anhydrate of crystalline S-(-)-amlodipine maleate and a preparation method thereof. The anhydrate of crystalline S-(-)-amlodipine maleate exhibits excellent physical and chemical properties including non-hygroscopicity, solubility, therma
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(2008/12/05)
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- Process for preparation of chiral amlodipine salts
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A process for the preparation of pharmaceutically acceptable salts of chiral Amlodipine namely S(?) Amlodipine and R(+) Amlodipine from without isolation of a free base from with optical purity rank between 96-99% is described in the present invention. The process comprises resolving RS amlodipine base using of L(+) or D(?) tartaric acid to obtain salt of corresponding to the acid used in ee rang from 96-99%.
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(2008/06/13)
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- A process for the preparation of s (-) amlodipine salts
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Described herein is a process for the preparation of S(-)Amlodipine salts which comprises reaction of S(-)Amlodipine base with a solution of pharmaceutically acceptable acid such as benzene sulfonic acid, oxalic acid, maleic acid, succinic acid and p-toluene sulfonic acid. The reaction is carried out in the presence of an organic solvent at room temperature. The organic solvents include alcohols like ethanol, methanol, 2-propanol, hydrocarbons like toluene and polar solvents like dimethyl sulfoxide. The salt is obtained by addition of water and isolation of the salt formed by filtration. The unique feature of the invention is production of S(-) Amlodipine besylate in good chemical yield, high enantiomeric purity and with the quality required for preparation of pharmaceutical composition i.e. tablet formulation.
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(2008/06/13)
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