135980-47-1Relevant articles and documents
Thermoplastic polymer composition
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Page/Page column 52; 53, (2015/12/17)
The invention provides a compound conforming to the structure of Formula (C) The invention also provides a thermoplastic polymer composition comprising a polyolefin polymer and a compound conforming to the structure of Formula (C) as a nucleating agent.
Molecular design, synthesis and biological evaluation of cyclic imides bearing benzenesulfonamide fragment as potential COX-2 inhibitors. Part 2
Al-Suwaidan, Ibrahim A.,Alanazi, Amer M.,El-Azab, Adel S.,Al-Obaid, Abdulrahman M.,Eltahir, Kamal E.H.,Maarouf, Azza R.,Abu El-Enin, Mohamed A.,Abdel-Aziz, Alaa A.-M.
, p. 2601 - 2605 (2013/06/27)
A group of cyclic imides (1-10) was designed for evaluation as a selective COX-2 inhibitors and investigated in vivo for their anti-inflammatory activity. Compounds 6a, 6b, 8a, 8b, 9a, 9b, 10a and 10b were proved to be potent COX-2 inhibitors with IC50 range of 0.1-4.0 μM. In vitro COX-1/COX-2 inhibition structure-activity studies identified compound 8a as a highly potent (IC50 = 0.1 μM), and an extremely selective [COX-2 (SI) > 1000] comparable to celecoxib [COX-2 (SI) > 384], COX-2 inhibitor that showed superior anti-inflammatory activity (ED50 = 72.4 mg/kg) relative to diclofenac (ED50 = 114 mg/kg). Molecular modeling was carried out through docking the designed compounds into the COX-2 binding site to predict if these compounds have analogous binding mode to the COX-2 inhibitors. The study showed that the homosulfonamide fragment of 8a inserted deep inside the 2 -pocket of the COX-2 active site, where the SO2NH2 group underwent H-bonding interaction with Gln192(2.95 A?), Phe 518(2.82 A?) and Arg513(2.63 and 2.73 A?). Docking study of the synthesized compound 8a into the active site of COX-2 revealed a similar binding mode to SC-558, a selective COX-2 inhibitor.
Synthesis, molecular modeling study, preliminary antibacterial, and antitumor evaluation of N-substituted naphthalimides and their structural analogues
El-Azab, Adel S.,Alanazi, Amer M.,Abdel-Aziz, Naglaa I.,Al-Suwaidan, Ibrahim A.,El-Sayed, Magda A. A.,El-Sherbeny, Magda A.,Abdel-Aziz, Alaa A.-M.
, p. 2360 - 2375 (2013/07/26)
Carboxylic acid imides 1-26 have been synthesized and screened for their antibacterial against gram-positive and gram-negative organisms and their antitumor activity against 60 tumor cell lines taken from nine different organs. Compounds 12, 14, and 16 we
The synthesis and fluorescence properties of macromolecular components based on 1,8-naphthalimide derivatives and dimers
El-Betany, Alaa M.M.,McKeown, Neil B.
supporting information; experimental part, p. 808 - 810 (2012/03/22)
A series of novel 1,8-naphthalimide derivatives and dimers possessing reactive carboxylic acid, nitro, amine, or bromide functionality is prepared and their photophysical properties are studied. Those derivatives that contain amine substituents attached d
Structures of bifunctional molecules containing two very different supramolecular synthons: Carboxylic acid and strong π...π stacking 1,8-naphthalimide ring
Reger, Daniel L.,Debreczeni, Agota,Horger, Jacob J.,Smith, Mark D.
experimental part, p. 4068 - 4079 (2012/03/13)
A series of molecules containing a carboxylic acid and a 1,8-naphthalimide group joined by different linkers (HLC1 = CH2; HL C2 = CH2CH2; HLC3 = CH 2CH2CH2;
Use of Rylene Derivatives as Photosensitizers in Solar Cells
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Page/Page column 38, (2008/12/04)
Use of rylene derivatives I with the following definition of the variables: X together both —COOM; Y a radical -L-NR1R2 ??(y1) -L-Z-R3 ??(y2) the other radical hydrogen; together both hydrogen; R is optionally substituted (het)aryloxy, (het)arylthio; P is —NR1R2; B is alkylene; optionally substituted phenylene; combinations thereof; A is —COOM; —SO3M; —PO3M2; D is optionally substituted phenylene, naphthylene, pyridylene; M is hydrogen; alkali metal cation; [NR5]4+; L is a chemical bond; optionally indirectly bonded, optionally substituted (het)arylene radical; R1, R2 are optionally substituted (cyclo)alkyl, (het)aryl; together optionally substituted ring comprising the nitrogen atom; Z is —O—; —S—; R3 is optionally substituted alkyl, (het)aryl; R′ is hydrogen; optionally substituted (cyclo)alkyl, (het)aryl; R5 is hydrogen; optionally substituted alkyl (het)aryl; m is 0, 1, 2; n, p m=0: 0, 2, 4 where: n+p=2, 4, if appropriate 0; m=1: 0, 2, 4 where: n+p=0, 2, 4; m=2: 0, 4, 6 where: n+p=0, 4, 6, or of mixtures thereof as photosensitizers in solar cells.
