An improved method for the preparation of formyldeuteroporphyrins - Synthesis of biologically relevant porphyrins
Pure 3 and 8 formyldeuteroporphyrin dimethylester isomers 3a,b have been prepared in high yield by formylation of readily accessible deuteroporphyrin dimethylester 1 with trimethyl orthoformate in trifluoroacetic acid and subsequent chromatographic separation of the mixture of isomers. The formylporphyrins can be transformed into synthetically and biologically useful derivatives.
Montforts, Franz-Peter,Scheurich, Gerhard,Meier, Axel,Haake, Gerold,Hoeper, Frank