- Indium-mediated reduction of β-nitrostyrenes to oximes in aqueous media
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β-Nitrostyrenes are selectively reduced to the corresponding oximes in high yields by indium metal in aqueous methanol under neutral reaction conditions.
- Yadav,Subba Reddy,Srinivas,Ramalingam
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p. 1447 - 1449
(2007/10/03)
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- Reduction of conjugated nitroalkenes with zinc borohydride. A mild method for converting monosubstituted nitroalkenes to nitroalkanes and disubstituted ones to oximes
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Mono-β-substituted conjugated nitroalkenes are readily reduced by zinc borohydride in 1,2-dimethoxyethane to the corresponding nitroalkanes, whereas the disubstituted ones furnish the corresponding oximes in excellent yields.
- Ranu,Chakraborty
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p. 5317 - 5322
(2007/10/02)
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- Highly Selective Reduction of Conjugated Nitroalkenes with Zinc Borohydride in DME
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Zinc borohydride in 1,2-dimethoxyethane reduces α-substituted conjugated nitroalkenes to the corresponding oximes and non-α-substituted ones to the corresponding nitroalkanes in excellent yields.
- Ranu, Brindaban C.,Chakraborty, Rupak
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p. 3579 - 3582
(2007/10/02)
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- Centrally active N-substituted analogs of 3,4-methylenedioxyphenylisopropylamine (3,4-methylenedioxyamphetamine)
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The known central nervous system activity of 3,4-methylenedioxyphenylisopropylamine and its N-methyl homolog prompted the synthesis of a series of analogs with substituents on the nitrogen atom. Most of these analogs (R = alkyl, alkenyl, hydroxy, alkoxy, and alkoxyalkyl) were prepared by the reductive alkylation of 3,4-methylenedioxyphenylacetone with the appropriate amine and sodium cyanoborohydride. Hindered isomers were synthesized indirectly. Measurements of their pharmacological activity in several animal assays and in human subjects indicated that the central activity decreased with the increasing bulk of the N-substituent.
- Braun,Shulgin,Braun
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p. 192 - 195
(2007/10/02)
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