136117-71-0

Basic information

• Product Name: (6-BROMOIMIDAZO[1,2-A]PYRIDIN-2-YL)METHANOL
• Synonyms: (6-BROMOIMIDAZO[1,2-A]PYRIDIN-2-YL)METHANOL;IMidazo[1,2-a]pyridine-2-Methanol, 6-broMo-
• CAS NO: 136117-71-0
• Molecular Formula: C8H7BrN2O
• Molecular Weight: 227.07
• Product Categories: Hydroxymethyl's;Fused Ring Systems
• Mol File: 136117-71-0.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (6-BROMOIMIDAZO[1,2-A]PYRIDIN-2-YL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (6-BROMOIMIDAZO[1,2-A]PYRIDIN-2-YL)METHANOL(136117-71-0)
• EPA Substance Registry System: (6-BROMOIMIDAZO[1,2-A]PYRIDIN-2-YL)METHANOL(136117-71-0)

Safety Data

• Hazardous Substances Data: 136117-71-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(6-Bromoimidazo[1,2-a]pyridin-2-yl)methanol is used as a key intermediate in the development of pharmaceuticals for its potential antiparasitic, antifungal, and antitumor properties. Its unique structure allows for the creation of new drugs that can target a variety of diseases and conditions.
Used in Agrochemical Industry:
In the agrochemical field, (6-Bromoimidazo[1,2-a]pyridin-2-yl)methanol is utilized as a building block for the synthesis of compounds with pesticidal properties. Its potential applications include the development of new fungicides, herbicides, and insecticides to protect crops and enhance agricultural productivity.
Used in Chemical Synthesis:
(6-Bromoimidazo[1,2-a]pyridin-2-yl)methanol is used as an intermediate in the production of other chemical compounds. Its versatility in chemical reactions makes it a valuable component in the synthesis of a wide range of organic molecules for various applications across different industries.

Upstream product

• 67625-37-0 ethyl 6-bromoimidazo<1,2-a>pyridine-2-carboxylate 
• 1072-97-5 5-bromo-2-pyridylamine 

Downstream Products

• 136117-72-1 6-bromo-2-(chloromethyl)imidazo[1,2-a]pyridine 

Relevant articles and documents

BICYCLIC PYRIDINE, PYRAZINE, AND PYRIMIDINE DERIVATIVES AS PI3K BETA INHIBITORS

The present invention relates to bicyclic pyridine, pyrazine, and pyrimidine derivatives of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as pI3Kβ inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Imidazo[1,2-a]pyridines. Synthesis and inotropic activity of new 5-imidazo[1,2-a]pyridinyl-2(1H)-pyridinone derivatives

A series of 1,2-dihydro-5-imidazo[1,2-a]pyridinyl-2(1H)-pyridinones was synthesized and evaluated for positive inotropic activity. 1,2-Dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-3- pyridinecarbonitrile (11a) hydrochloride monohydrate (E-1020) was found to be a potent and selective inhibitor of phosphodiesterase III and a long-acting, potent, orally active positive inotropic agent. Additional imidazo[1,2-a]pyridin-2-yl (3a), -3-yl (16), -7-yl (20) and -8-yl (24a) compounds were also prepared. Altering the pyridine substitution from the 2-position to the 6-position produced a 2-fold increase in the i.v. cardiotonic potency (ED50) from 52 to 23 μg/kg, while substitution at the 3-, 7- or 8-position reduced potency. In the 2-positional isomers, introduction of halogen groups enhanced the activity and 3-chloro-1,2-dihydro-5-(6-fluoroimidazo[1,2-a]pyridin-2-yl)-6-methyl-2(1H)- pyridinone (3a) was the most potent (i.v. ED50 11 μg/kg) in this seris. E-1020 is presently under development for the treatment of congestive heart failure.