- Synthesis of (14C6-3,4,7,8,11,12)-(1E,5E,9E)- cyclododeca-1,5,9-triene
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Trimerization of butadiene in the presence of Ni(0) affords (1E,5E,9E)-cyclododeca-1,5,9-triene 1 (ttt-CDT), (1E,5E,9Z)-cyclododeca-1,5,9- triene 2 (ttc-CDT), and other isomers/oligomers. After optimization of reaction conditions, [14C6-3,4,7,8,11,12]-ttt-CDT 1 was synthesized efficiently either by homogenous or heterogeneous Ni(0) catalytic trimerization of [1,4-14C2]butadiene 10, in 60-82% yield. Depending on the exact reaction conditions employed, the yields and ratio of 1/2 ranged from (59-90%) / (41-10%). The all-trans isomer was conveniently isolated via Ag +-mediated reversed-phase HPLC. The important intermediate [1,4- 14C2]-1,3-butadiene 10 was prepared from potassium [ 14C]cyanide and 1,2-dibromoethane 3 as starting materials, in seven steps with a 57% yield. The total radioactive yield of [14C 6-3,4,7,8,11,12]-ttt-CDT 1 is 30% from [14C]KCN. Copyright
- Diel, Bruce N.,Han, Mingcheng,White, Jonathan M.
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