Structure-based optimization of FDA-approved drug methylene blue as a c-myc G-quadruplex DNA stabilizer
G-quadruplexes are non-canonical DNA secondary structures putatively present in the promoter regions of oncogenes in the human genome. The targeting of promoter G-quadruplex structures to repress oncogene transcription represents a potential anticancer st
Chan, Daniel Shiu-Hin,Yang, Hui,Kwan, Maria Hiu-Tung,Cheng, Zhen,Lee, Paul,Bai, Li-Ping,Jiang, Zhi-Hong,Wong, Chun-Yuen,Fong, Wang-Fun,Leung, Chung-Hang,Ma, Dik-Lung
p. 1055 - 1064
(2012/03/22)
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