1362625-86-2

Basic information

• Product Name: C₂₂H₂₉N₃O₃
• CAS NO: 1362625-86-2
• Molecular Weight: 383.491
• Mol File: 1362625-86-2.mol

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₉N₃O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₉N₃O₃(1362625-86-2)
• EPA Substance Registry System: C₂₂H₂₉N₃O₃(1362625-86-2)

Safety Data

• Hazardous Substances Data: 1362625-86-2(Hazardous Substances Data)

Upstream product

• 621-59-0 isovanillin 
• 1362623-54-8 3-benzyloxy-4-methoxy-phenyl isocyanate 
• 1362624-37-0 (S)-1-(3-benzyloxy-4-methoxyphenyl)-3-(1-phenyl-ethyl)-urea 
• 54035-94-8 N-(2-bromoethyl)pyrrolidine 
• 1362624-32-5 (S)-1-(3-hydroxy-4-methoxyphenyl)-3-(1-phenyl-ethyl)-urea 
• 58452-00-9 3-benzyloxy-4-methoxybenzoic acid 
• 6346-05-0 3-benzyloxy-4-methoxybenzaldehyde 

Relevant articles and documents

Discovery and structural modification of 1-phenyl-3-(1-phenylethyl)urea derivatives as inhibitors of complement

A series of 1-phenyl-3-(1-phenylethyl)urea derivatives were identified as novel and potent complement inhibitors through structural modification of the original compound from high-throughput screening. Various analogues (7 and 13-15) were synthesized and identified as complement inhibitors, with the introduction of a five- or six-carbon chain (7c, 7d, 7k, 7l, and 7o) greatly improving their activity. Optimized compound 7l has an excellent inhibition activity with IC50 values as low as 13 nM. We demonstrated that the compound 7l inhibited C9 deposition through the classical, the lectin, and the alternative pathways but had no influence on C3 and C4 depositions.