Synthesis of 3-ureido derivatives of coumarin and 2-quinolone as potent Acyl-CoA: Cholesterol acyltransferase inhibitors
Novel 3-ureido derivatives of 4-phenylcoumarin and 4-phenyl-2-quinolone were synthesized and evaluated for acyl-CoA: cholesterol acyltransferase (ACAT)-inhibitory activity. These derivatives inhibited rat intestinal ACAT with IC50 values at the 10-8 to 10-9 M level and were found to normalize plasma cholesterol levels in cholesterol-fed rats when administered as dietary admixtures.
Tawada,Natsugari,Ishikawa,Sugiyama,Ikeda,Meguro
p. 616 - 625
(2007/10/02)
Quinoline derivatives, their production and use
A quinoline derivative of the formula (I): STR1 wherein each phenyl ring of A, B and C can have one or more substituents, X is STR2 (R1 is a hydrogen atom or a lower alkyl group) or STR3 (R2 is a lower alkyl group or a lower alkoxy g
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(2008/06/13)
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