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CAS

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1363383-18-9

Tert-butyl 7-hydroxy-2-azaspiro[3.5]nonane-2-carboxylate is a chemical compound with a unique structure that features a spiro-linked azaspiro-nonane core and a carboxylate group. It is known for its potential applications in the pharmaceutical industry due to its ability to act as an ATX (autocrine motility factor) inhibitor.

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  • 2-AZASPIRO[3.5]NONANE-2-CARBOXYLIC ACID, 7-HYDROXY-, 1,1-DIMETHYLETHYL ESTER

    Cas No: 1363383-18-9

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  • 1363383-18-9 Structure

  • Basic information

    1. Product Name: tert-butyl 7-hydroxy-2-azaspiro[3.5]nonane-2-carboxylate
    2. Synonyms: tert-butyl 7-hydroxy-2-azaspiro[3.5]nonane-2-carboxylate;2-Azaspiro[3.5]nonane-2-carboxylic acid, 7-hydroxy-, 1,1-diMethylethyl ester;7-Hydroxy-2-azaspiro[3.5]nonane-2-carboxylic acid 1,1-dimethylethyl ester;2-Boc-7-hydroxy-2-azaspiro[3.5]nonane - B7199
    3. CAS NO:1363383-18-9
    4. Molecular Formula: C13H23NO3
    5. Molecular Weight: 241.32662
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1363383-18-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 350.7±42.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.12±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: Sealed in dry,Room Temperature
    8. Solubility: N/A
    9. PKA: 15.07±0.20(Predicted)
    10. CAS DataBase Reference: tert-butyl 7-hydroxy-2-azaspiro[3.5]nonane-2-carboxylate(CAS DataBase Reference)
    11. NIST Chemistry Reference: tert-butyl 7-hydroxy-2-azaspiro[3.5]nonane-2-carboxylate(1363383-18-9)
    12. EPA Substance Registry System: tert-butyl 7-hydroxy-2-azaspiro[3.5]nonane-2-carboxylate(1363383-18-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1363383-18-9(Hazardous Substances Data)

1363383-18-9 Usage

Uses

Used in Pharmaceutical Industry:
Tert-butyl 7-hydroxy-2-azaspiro[3.5]nonane-2-carboxylate is used as an ATX inhibitor for the treatment of cancers and fibrotic diseases. Its inhibitory action on ATX can help in disrupting the growth and progression of cancer cells, as well as reducing the severity of fibrotic conditions by targeting the underlying molecular mechanisms involved in these diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 1363383-18-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,6,3,3,8 and 3 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1363383-18:
(9*1)+(8*3)+(7*6)+(6*3)+(5*3)+(4*8)+(3*3)+(2*1)+(1*8)=159
159 % 10 = 9
So 1363383-18-9 is a valid CAS Registry Number.

1363383-18-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl 7-hydroxy-2-azaspiro[3.5]nonane-2-carboxylate

1.2 Other means of identification

Product number -
Other names 2-Boc-7-hydroxy-2-azaspiro[3.5]nonane

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1363383-18-9 SDS

1363383-18-9Relevant articles and documents

A spiro compound, its preparation method, composition and use thereof

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Paragraph 0126; 0127; 0128; 0129, (2018/07/30)

The invention discloses a spiro compound, preparation method thereof, and use of the composition. The spiro compounds have the following formula (I) structure. The invention spiro compounds can be effective therapy [...] X receptor-mediated disease, more stable, long half-life.

SPIROCYCLIC MOLECULES AS PROTEIN KINASE INHIBITORS

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Paragraph 00234-00236, (2013/03/26)

The present invention relates to spirocyclic compounds of formula I, namely spirocyclic (1H-pyrazol-4-yl)-3-(1-(2,6-dichloro-3-fiuorophenyl) ethoxy)pyridin-2-amines having protein kinase inhibitory activity, and methods of synthesizing and using such compounds. Preferred compounds are c-Met and/or ALK inhibitors useful for the treatment of abnormal cell growth, such as cancers

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