1363383-18-9Relevant articles and documents
A spiro compound, its preparation method, composition and use thereof
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Paragraph 0126; 0127; 0128; 0129, (2018/07/30)
The invention discloses a spiro compound, preparation method thereof, and use of the composition. The spiro compounds have the following formula (I) structure. The invention spiro compounds can be effective therapy [...] X receptor-mediated disease, more stable, long half-life.
SPIROCYCLIC MOLECULES AS PROTEIN KINASE INHIBITORS
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Paragraph 00234-00236, (2013/03/26)
The present invention relates to spirocyclic compounds of formula I, namely spirocyclic (1H-pyrazol-4-yl)-3-(1-(2,6-dichloro-3-fiuorophenyl) ethoxy)pyridin-2-amines having protein kinase inhibitory activity, and methods of synthesizing and using such compounds. Preferred compounds are c-Met and/or ALK inhibitors useful for the treatment of abnormal cell growth, such as cancers