136375-93-4

Basic information

• Product Name: N-benzyloctahydro-1H-2,4,1-(ethane[1,1,2]triyl)cyclobuta[cd]pentalen-5-amine
• CAS NO: 136375-93-4
• Molecular Formula: C₁₈H₂₁N
• Molecular Weight: 251.366
• Mol File: 136375-93-4.mol

Chemical Properties

• Boiling Point: 375.9°C at 760 mmHg
• Flash Point: 191.8°C
• Density: 1.22g/cm³
• Vapor Pressure: 7.51E-06mmHg at 25°C
• Refractive Index: 1.654
• CAS DataBase Reference: N-benzyloctahydro-1H-2,4,1-(ethane[1,1,2]triyl)cyclobuta[cd]pentalen-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyloctahydro-1H-2,4,1-(ethane[1,1,2]triyl)cyclobuta[cd]pentalen-5-amine(136375-93-4)
• EPA Substance Registry System: N-benzyloctahydro-1H-2,4,1-(ethane[1,1,2]triyl)cyclobuta[cd]pentalen-5-amine(136375-93-4)

Safety Data

• Hazardous Substances Data: 136375-93-4(Hazardous Substances Data)

Upstream product

• 69649-19-0 pentacyclo[5.4.0.0^2,6.0^3,10.0^5,8]undecane-8-one 
• 100-46-9 benzylamine 

Relevant articles and documents

Structure-activity relationships of polycyclic aromatic amines with calcium channel blocking activity

8-Benzylamino-8,11- oxapentacyclo[5.4.0.02,6.033,10.05,9]undecane (1) inhibits the calcium current in L-type calcium channels. A series of nitrobenzylamines (2, 3, 4), methoxybenzylamines (5,6, 7), methylpyridines (8, 9m 10), and a phenylhydrazine derivative (11) of 8,11- oxapentacyclo[5.4.0.02,6.03,105,9]undecane was synthesized. By substituting the 8,11-oxapentacyclo- [5.4.0.02,6.03,10.05,9]undecane skeleton with 3-hydroxyhexacyclo- [6.5.0.03,7.04,12.05,10.09,10]tridecane (12), 8,13- dioxapentacyclo[6.5.0.02,6.05,10.03.11]tridecane-9-one (13), and pentacyclo[5.4.0.02,6.03,10.05,9]undecane (14), the effect of the polycyclic skeleton could also be investigated. Increased inhibition of calcium current was observed with aromatic substitution (especially ortho and meta substitution) in the pentacycloundecane series. The calcium channel activities of the methoxy compounds were slightly higher than those of the corresponding nitro compounds while a definite decrease in activity was observed for the phenylhydrazine and aminomethylpyridine derivatives. Increased inhibition of the calcium current was also observed for structures in which the polycyclic 'cages' were enlarged. Structure-activity relationships in this series of compounds therefore appear to be dominated by geometric or steric constraints.

Pentacyclo[5.4.0.02,6.03,10.05,9]undecylamines. Synthesis and pharmacology

The synthesis and biological activity of a series of pentacyclo[5.4.0.02,6.03,10.05,9]undecyl-8-amino derivatives are described. The activity of the compounds to antagonize the reserpine induced catatonia (anticataleptic) and their ability to reduce the oxotremorine induced tremor and salivation were determined in order to evaluate their potential as anti-Parkinson agents. Promising anticataleptic and mild to weak anticholinergic activities were observed for these compounds. The influence of substituents is discussed.