136401-56-4

Basic information

• Product Name: 4-[2-(2-pyridyl)ethylsulfanyl]aniline
• CAS NO: 136401-56-4
• Molecular Formula: C₁₃H₁₄N₂S
• Molecular Weight: 230.3287
• Mol File: 136401-56-4.mol

Chemical Properties

• Boiling Point: 417.7°C at 760 mmHg
• Flash Point: 206.4°C
• Density: 1.19g/cm³
• Vapor Pressure: 3.47E-07mmHg at 25°C
• Refractive Index: 1.644
• CAS DataBase Reference: 4-[2-(2-pyridyl)ethylsulfanyl]aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-(2-pyridyl)ethylsulfanyl]aniline(136401-56-4)
• EPA Substance Registry System: 4-[2-(2-pyridyl)ethylsulfanyl]aniline(136401-56-4)

Safety Data

• Hazardous Substances Data: 136401-56-4(Hazardous Substances Data)

Usage

General Description

4-[2-(2-pyridyl)ethylsulfanyl]aniline is a chemical compound with the molecular formula C13H13N3S. It is also known as 2-(2-pyridyl)ethyl p-tolylsulfane in IUPAC nomenclature. 4-[2-(2-pyridyl)ethylsulfanyl]aniline is a derivative of aniline, with a sulfur atom attached to the carbon in the para position of the aniline ring and a 2-pyridyl ethyl group attached to the nitrogen atom. It is commonly used in organic synthesis and pharmaceutical research. 4-[2-(2-pyridyl)ethylsulfanyl]aniline has a wide range of potential applications, including as a building block for the synthesis of various organic compounds and as a precursor for the development of new pharmaceutical drugs. It should be handled with care, as it may be hazardous if not properly managed.

Upstream product

• 100-69-6 2-vinylpyridine 
• 1193-02-8 4-aminotiophenol 

Downstream Products

• 136401-94-0 methyl 2-bromo-3-<4-<2-(2-pyridyl)ethylthio>phenyl>propionate 
• 136401-57-5 5-<4-<2-(2-Pyridyl)ethylthio>benzyl>-2,4-thiazolidinedione 
• 136401-78-0 2-imino-5-<4-<2-(2-pyridyl)ethylthio>benzyl>-4-thiazolidinone 

Relevant articles and documents

Benzamide compounds as apo b secretion inhibitors

The present invention relates to compounds of the formula (I) wherein R1 and R2 are each independently lower alkyl lower alkenyl, acyl, amino, lower alkoxy, lower cycloalkyloxy, aryl, aryloxy, sulfooxy, mercapto, sulfo, hydrogen, halogen, nitro, cyano or hydroxy, or may form a ring structure; Q1 is N or CH; L is optionally substituted unsaturated 3 to 10-membered heterocyclic group; X is optionally substituted monocyclic arylene or monocyclic heteroarylene; Y is -(A1)m-(A2)n-(A4)k-; Z is directbond, —CH2-, —NH— or —O—; and R is hydrogen or lower alkyl, or a salt thereof The compounds of the present invention inhibit apolipoprotein B (Apo B) secretion and are useful as a medicament for prophylactic and treatment of diseases or conditions resulting from elevated circulating levels of Apo B.

Studies on antidiabetic agents. X. Synthesis and biological activities of pioglitazone and related compounds

Various analogues of a new antidiabetic agent, pioglitazone (AD-4833, U-72107), were synthesized in order to study in more detail the structure-activity relationships of this class of drug. 5-(4-Pyridylalkylthiobenzyl)-2,4-thiazolidinediones (I), this-analogues of pioglitazone, were prepared via Meerwein arylation of the alkylthioanilines (IV). 5-(4-Pyridylalkoxybenzylidene)-2,4-thiazolidinediones (IIa) and related heterocyclic analogues (IIb) were synthesized by Knoevenagel condensation of the aldehydes (VIII) with the corresponding azolidinones. Compounds I and II were evaluated for hypoglycemic and hypolipidemic activity in genetically obese and diabetic yellow KK (KKA(y)) mice. Several 5-[4-[2-(2-pyridyl)ethoxy]-benzylidene]-2,4-thiazolidinediones (IIa) were equipotent to pioglitazone. However, the thia-analogues (I) and the benzylideneheterocycles (IIb) had decreased activity. Catalytic hydrogenation of the 5-benzylidene analogue (14) was found to be a convenient new synthetic method for pioglitazone. The configuration of 14 is also discussed.