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CAS

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136450-11-8

N-(2-Cyano-4-oxo-4H-1-benzopyran-8-yl)-4-(4-phenylbutoxy)benzamide, commonly referred to as BAY 11-7082, is a synthetic benzamide compound with significant pharmaceutical interest. It has been extensively studied for its ability to inhibit the activation of the transcription factor NF-κB, a key player in inflammatory and immune responses. BAY 11-7082's potential applications span across various therapeutic areas, including anti-inflammatory, anti-cancer, and neuroprotective effects, making it a promising candidate for the treatment of a range of diseases.

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  • N-(2-Cyano-4-oxo-4H-1-benzopyran-8-yl)-4-(4-phenylbutoxy)benzamide

    Cas No: 136450-11-8

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  • N-(2-Cyano-4-oxo-4H-1-benzopyran-8-yl)-4-(4-phenylbutoxy)benzamide

    Cas No: 136450-11-8

  • USD $ 1.9-2.9 / Gram

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  • 136450-11-8 Structure

  • Basic information

    1. Product Name: N-(2-Cyano-4-oxo-4H-1-benzopyran-8-yl)-4-(4-phenylbutoxy)benzamide
    2. Synonyms: N-(2-Cyano-4-oxo-4H-1-benzopyran-8-yl)-4-(4-phenylbutoxy)benzamide;N-(2-cyano-4-oxo-4H-chromen-8-yl)-4-(4-phenylbutoxy)benzamide;N-(2-cyano-4-oxochromen-8-yl)-4-(4-phenylbutoxy)benzamide
    3. CAS NO:136450-11-8
    4. Molecular Formula: C27H22N2O4
    5. Molecular Weight: 438.47
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 136450-11-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 574.009 °C at 760 mmHg
    3. Flash Point: 300.95 °C
    4. Appearance: /
    5. Density: 1.30
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N-(2-Cyano-4-oxo-4H-1-benzopyran-8-yl)-4-(4-phenylbutoxy)benzamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-(2-Cyano-4-oxo-4H-1-benzopyran-8-yl)-4-(4-phenylbutoxy)benzamide(136450-11-8)
    11. EPA Substance Registry System: N-(2-Cyano-4-oxo-4H-1-benzopyran-8-yl)-4-(4-phenylbutoxy)benzamide(136450-11-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 136450-11-8(Hazardous Substances Data)

136450-11-8 Usage

Uses

Used in Pharmaceutical Research:
BAY 11-7082 is used as a research tool for studying the role of NF-κB in various biological processes. Its ability to inhibit NF-κB activation provides insights into the mechanisms of inflammation, immune response, and cell survival, contributing to the development of novel therapeutic strategies.
Used in Anti-inflammatory Applications:
BAY 11-7082 is used as an anti-inflammatory agent, targeting the NF-κB pathway to reduce inflammation in various conditions. Its potential use in treating inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease, is currently under investigation.
Used in Cancer Therapy:
BAY 11-7082 is used as an anti-cancer agent, leveraging its NF-κB inhibitory properties to suppress tumor growth and proliferation. Its potential application in treating various types of cancer, including solid tumors and hematological malignancies, is being explored in preclinical and clinical studies.
Used in Neuroprotection:
BAY 11-7082 is used as a neuroprotective agent, with its NF-κB inhibitory activity potentially offering protection against neurodegenerative disorders. Its application in conditions such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis is being investigated for its potential to mitigate neuroinflammation and neuronal damage.
Used in Drug Development:
BAY 11-7082 serves as a lead compound in the development of novel therapeutic agents targeting the NF-κB pathway. Its derivatives and analogs are being synthesized and evaluated for improved potency, selectivity, and pharmacokinetic properties, with the aim of advancing new drugs for the treatment of various diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 136450-11-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,4,5 and 0 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 136450-11:
(8*1)+(7*3)+(6*6)+(5*4)+(4*5)+(3*0)+(2*1)+(1*1)=108
108 % 10 = 8
So 136450-11-8 is a valid CAS Registry Number.

136450-11-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(2-cyano-4-oxochromen-8-yl)-4-(4-phenylbutoxy)benzamide

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:136450-11-8 SDS

136450-11-8Relevant articles and documents

Industrial preparation method of anti-asthma drug pranlukast intermediate

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Paragraph 0015-0020; 0022; 0024, (2020/04/17)

The invention discloses a preparation method of a pranlukast intermediate N-(2-cyano-4-oxo-4H-chromene-8-yl)-4-(4-butoxyphenyl)benzamide (short for formula I), specifically a method for preparing N-(2-cyano-4-oxo-4H-chromene-8-yl)-4-(4-butoxyphenyl)benzamide by carrying out a dewatering reaction on 4-oxo-8-[4-(4-butoxyphenyl)benzamide]-4H-chromene-2-formamide (short for formula II). The preparation method of the pranlukast intermediate represented by the formula I is high in yield, good in product color, high in product purity and beneficial to industrial production.

PROCESS FOR THE PREPARATION OF NITRILE COMPOUNDS

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Page/Page column 4, (2008/06/13)

A process for the preparation of a compound of formula (I) or a salt thereof wherein R is an amino, nitro or —NHCOR1 group, wherein R1 is C1-C6 alkyl or phenyl optionally substituted by a —O—(CH2)sub

A process for the preparation of nitrile compounds used as intermediates in the synthesis of cysteinyl leukotrienes antagonists

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Page/Page column 7, (2010/11/30)

A process for the preparation of a compound of formula (I) or a salt thereof wherein R is an amino, nitro or -NHCOR1 group, wherein R1 is C1-C6 alkyl or phenyl optionally substituted by a -O-(CH2)su

PROCESS FOR PRODUCING NITRILE COMPOUND

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Page 4, (2008/06/13)

Processes for the preparation of the nitrile compound of formula (1). According to the present invention, the compound of formula (I) can be prepared cheaply and simply, therefore, the present invention is excellent as the industrial mass production metho

PROCESS FOR PRODUCING CHROMONE COMPOUND

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Page 24, 25, (2008/06/13)

A process for producing a dicarboxylic acid compound represented by the formula (4): wherein R1 and R2 are the same or different and each represents lower alkyl and the wavy line indicates that this compound is the E- or Z-isomer or

Process of producing 2-cyano-4-oxo-4H-benzopyran compounds

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, (2008/06/13)

There is disclosed a process of producing a 2-cyano-4-oxo-4H-benzopyran compound of the general formula (2): STR1 wherein R1 and R2 are independently hydrogen, halogen, hydroxy, C1 -C5 alkyl, C1 -Csu

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