The C2 amination of imidazo[4,5-b]pyridines was accomplished through C2 halogenation followed by substitution (SNAr) with functionalized primary and secondary amines. This regioselective sequence is operationally simple and provides an easy access to derivatives of protected imidazo[4,5-b]pyridines. The Royal Society of Chemistry 2013.
Rosenberg, Adam J.,Williams, Theresa M.,Jordan, Abraham J.,Clark, Daniel A.
p. 3064 - 3072
(2013/07/25)
Synthesis of imidazo[4,5-b]pyridines and imidazo[4,5-b]pyrazines by palladium catalyzed amidation of 2-chloro-3-amino-heterocycles
A facile synthesis of imidazo[4,5-b]pyridines and-pyrazines is described using a Pd-catalyzed amide coupling reaction. This reaction provides quick access to products with substitution at N1 and C2. A model system relevant to the natural product pentosidi
Rosenberg, Adam J.,Zhao, Jinbo,Clark, Daniel A.
p. 1764 - 1767
(2012/05/20)
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