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3'-NITROBIPHENYL-3-OL, also known as 3'-nitro-3-hydroxybiphenyl, is a chemical compound with the molecular formula C12H9NO3. It is a nitrophenyl derivative, specifically a nitrobenzene and a nitrophenol, characterized by its yellow crystalline solid form. 3'-NITROBIPHENYL-3-OL is insoluble in water but soluble in organic solvents. Due to its toxic and carcinogenic properties, 3'-NITROBIPHENYL-3-OL has been identified as a potential endocrine disruptor and is regulated under the Toxic Substances Control Act in the United States. It is primarily used as a building block in the synthesis of pharmaceuticals and dyes.

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  • 136539-67-8 Structure
  • Basic information

    1. Product Name: 3'-NITROBIPHENYL-3-OL
    2. Synonyms: 3'-NITROBIPHENYL-3-OL
    3. CAS NO:136539-67-8
    4. Molecular Formula: C12H9NO3
    5. Molecular Weight: 215.2
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 136539-67-8.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: 3'-NITROBIPHENYL-3-OL(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3'-NITROBIPHENYL-3-OL(136539-67-8)
    11. EPA Substance Registry System: 3'-NITROBIPHENYL-3-OL(136539-67-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 136539-67-8(Hazardous Substances Data)

136539-67-8 Usage

Uses

Used in Pharmaceutical Industry:
3'-NITROBIPHENYL-3-OL is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Dye Industry:
3'-NITROBIPHENYL-3-OL is used as a building block in the production of dyes. Its chemical properties make it suitable for creating a range of colorants used in various applications, including textiles, plastics, and printing inks.

Check Digit Verification of cas no

The CAS Registry Mumber 136539-67-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,5,3 and 9 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 136539-67:
(8*1)+(7*3)+(6*6)+(5*5)+(4*3)+(3*9)+(2*6)+(1*7)=148
148 % 10 = 8
So 136539-67-8 is a valid CAS Registry Number.

136539-67-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 3'-Nitro-[1,1'-biphenyl]-3-ol

1.2 Other means of identification

Product number -
Other names 3-(3-nitrophenyl)phenol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:136539-67-8 SDS

136539-67-8Relevant articles and documents

Syntheses of 3-arylphenols from (3-aryl-3-oxopropyl)dialkylammonium chlorides and 1-(2-Oxopropyl)pyridinium chloride

Eichinger,Nussbaumer

, p. 663 - 664 (1991)

The reactions of (3-aryl-3-oxopropyl)dialkylammonium chlorides 1a-f with 1-(2-oxopropyl)pyridinium chloride (2) and triethylamine gave the 3-arylphenols 3a-f with yields from 43 to 83%.

DIARYLUREAS AS CB1 ALLOSTERIC MODULATORS

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Paragraph 69; 72; 80, (2018/12/02)

The present invention provides novel diarylurea derivatives (compounds of formula (I)) and their uses. The compounds of the present invention are demonstrated to be allosteric modulators of the CB1 receptor, and therefore useful for the treatment of diseases and conditions mediated by CB1.

Novel Diarylurea Based Allosteric Modulators of the Cannabinoid CB1 Receptor: Evaluation of Importance of 6-Pyrrolidinylpyridinyl Substitution

Nguyen, Thuy,German, Nadezhda,Decker, Ann M.,Langston, Tiffany L.,Gamage, Thomas F.,Farquhar, Charlotte E.,Li, Jun-Xu,Wiley, Jenny L.,Thomas, Brian F.,Zhang, Yanan

, p. 7410 - 7424 (2017/09/22)

Allosteric modulators of the cannabinoid CB1 receptor have recently been reported as an alternative approach to modulate the CB1 receptor for therapeutic benefits. In this study, we report the design and synthesis of a series of diarylureas derived from PSNCBAM-1 (2). Similar to 2, these diarylureas dose-dependently inhibited CP55,940-induced intracellular calcium mobilization and [35S]GTP-γ-S binding while enhancing [3H]CP55,940 binding to the CB1 receptor. Structure-activity relationship studies revealed that the pyridinyl ring of 2 could be replaced by other aromatic rings and the pyrrolidinyl ring is not required for CB1 allosteric modulation. 34 (RTICBM-74) had similar potencies as 2 in all in vitro assays but showed significantly improved metabolic stability to rat liver microsomes. More importantly, 34 was more effective than 2 in attenuating the reinstatement of extinguished cocaine-seeking behavior in rats, demonstrating the potential of this diarylurea series as promising candidates for the development of relapse treatment of cocaine addiction.

Aerobic oxidative heck/dehydrogenation reactions of cyclohexenones: Efficient access to meta-substituted phenols

Izawa, Yusuke,Zheng, Changwu,Stahl, Shannon S.

, p. 3672 - 3675 (2013/04/23)

Jockeying for the (meta)position: A new dicationic palladium(II) catalyst, employing a 6,6′-dimethyl-2,2′-bipyridine ligand, promotes both the aerobic oxidative Heck coupling and dehydrogenation reactions of cyclohexenones. These reactions may be combined in a one-pot sequence to enable the straightforward synthesis of meta-substituted phenols (see scheme). Copyright

Cyclohexylcarbamic acid 3′- or 4′-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: Synthesis, quantitative structure-activity relationships, and molecular modeling studies

Mor, Marco,Rivara, Silvia,Lodola, Alessio,Plazzi, Pier Vincenzo,Tarzia, Giorgio,Duranti, Andrea,Tontini, Andrea,Piersanti, Giovanni,Kathuria, Satish,Piomelli, Daniele

, p. 4998 - 5008 (2007/10/03)

Fatty acid amide hydrolase (FAAH) is a promising target for modulating endocannabinoid and fatty acid ethanolamide signaling, which may have important therapeutic potential. We recently described a new class of O-arylcarbamate inhibitors of FAAH, includin

Aryl and heteroaryl sulfonates

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Page 15, (2008/06/13)

The invention relates to novel aryl and heteroaryl sulfonates of formula (Ia) and to methods for producing them and to novel aryl and heteroaryl sulfonates of formula (I) for treating and/or preventing diseases, especially for treating pain and neurodegen

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