cas 136562-04-4, 3-CYANO-5-ETHHYL-6-METHYLPYRIDIN-2(1H)-ONE | Articles data ｜lookchem

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136562-04-4

Articles about 136562-04-4Total 7 be found

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Condensation of 2-Methylbenzoxazole with Aromatic Aldehydes Bearing Acidic Protons. A Convenient Coupling in the Synthesis of the HIV-Reverse Transcriptase Inhibitor L-696,229
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Houpis, Ioannis N.,Molina, Audrey,Lynch, Joseph,Reamer, Robert A.,Volante, R. P.,Reider, Paul J.
p. 3176 - 3178
(1993)
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Studies towards 4-C-alkylation of pyridin-2(1H)-one derivatives.
In order to obtain 4-C-alkylated pyridin-2(1H)-ones, two strategies were studied: nucleophilic substitution of 4-chloro-3-nitropyridinone derivatives which essentially failed and lithiations of 2-methoxy-3-pivaloylaminopyridines which gave the expected products.
Dolle, Valerie,Nguyen, Chi Hung,Bisagni, Emile
p. 12505 - 12524
(2007/10/03)

Inhibitors of HIV reverse transcriptase
Novel aminopyridones inhibit HIV reverse transcriptase, and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
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(2008/06/13)

Synergism of HIV reverse transcriptase inhibitors
The combination of certain aminopyridones and anti-HIV nucleoside analogs has been found to synergistically inhibit HIV reverse transcriptase. This combination is useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as a combination of compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in further combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
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(2008/06/13)

Synthesis and evaluation of 2-pyridinone derivatives as HIV-1 specific reverse transcriptase inhibitors. 1. Phthalimidoalkyl and -alkylamino analogues
A potent (IC50 = 30 nM), specific nonnucleoside HIV-1 reverse transcriptase (RT) inhibitor 3-[N-(phthalimidomethyl)amino]-5-ethyl-6- methylpyridin-2(1H)-one (1), was discovered through an in vitro screening program. This compound did not inhibi
Hoffman,Wai,Thomas,Levin,O'Brien,Goldman
p. 3784 - 3791
(2007/10/02)

Inhibitors of HIV reverse transcriptase
Novel pyridones inhibit HIV reverse transcriptase, and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
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(2008/06/13)

2-pyridinone derivatives: A new class of nonucleoside, HIV-1-specific reverse transcriptase inhibitors [3]
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Saari,Hoffman,Wai,Fisher,Rooney,Smith,Thomas,Goldman,O'Brien,Nunberg,Quintero,Schleif,Emini,Stern,Anderson
p. 2922 - 2925
(2007/10/02)

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Chemical Properties

Boiling Point: 343.829°C at 760 mmHg
Flash Point:161.742°C
Density: 1.128g/cm³
Vapor Pressure: 0mmHg at 25°C
Refractive Index: 1.532
PKA: 9.40±0.10(Predicted)
PSA: 56.65000
LogP: 1.11738

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