Dioxindole in asymmetric catalytic synthesis: Direct access to 3-substituted 3-hydroxy-2-oxindoles via 1,4-additions to nitroalkenes
The asymmetric Michael addition of dioxindoles to β-substituted nitroalkenes is reported. The bifunctional primary amine-thiourea A, by means of a non-covalent-based mode of catalysis, secures direct access to 3-substituted 3-hydroxyoxindole derivatives with high stereocontrol. The Royal Society of Chemistry 2012.
Retini, Michele,Bergonzini, Giulia,Melchiorre, Paolo
p. 3336 - 3338
(2012/04/17)
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