13672-23-6

Basic information

• Product Name: (1-BENZYL-3-HYDROXY-2-OXO-2,3-DIHYDRO-1H-INDOL-3-YL)-ACETIC ACID
• Synonyms: (1-BENZYL-3-HYDROXY-2-OXO-2,3-DIHYDRO-1H-INDOL-3-YL)-ACETIC ACID;2-(1-Benzyl-3-hydroxy-2-oxoindolin-3-yl)acetic acid
• CAS NO: 13672-23-6
• Molecular Formula: C₁₇H₁₅NO₄
• Molecular Weight: 297.31
• Product Categories: pharmacetical
• Mol File: 13672-23-6.mol

Chemical Properties

• Boiling Point: 639.5 °C at 760 mmHg
• Flash Point: 340.6 °C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 3.14E-17mmHg at 25°C
• CAS DataBase Reference: (1-BENZYL-3-HYDROXY-2-OXO-2,3-DIHYDRO-1H-INDOL-3-YL)-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (1-BENZYL-3-HYDROXY-2-OXO-2,3-DIHYDRO-1H-INDOL-3-YL)-ACETIC ACID(13672-23-6)
• EPA Substance Registry System: (1-BENZYL-3-HYDROXY-2-OXO-2,3-DIHYDRO-1H-INDOL-3-YL)-ACETIC ACID(13672-23-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 13672-23-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Development:
(1-Benzyl-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-3-yl)-acetic acid is used as a key intermediate in the synthesis of pharmaceuticals for its unique structural features and potential biological activity.
Used in Chemical Research:
(1-BENZYL-3-HYDROXY-2-OXO-2,3-DIHYDRO-1H-INDOL-3-YL)-ACETIC ACID is utilized in chemical research to study the properties and reactions of indole derivatives, which can contribute to the development of new chemical processes and applications.
Used in Drug Design:
(1-Benzyl-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-3-yl)-acetic acid is employed in drug design for its potential to be incorporated into new drug molecules, offering novel therapeutic options for various medical conditions.

InChI:InChI=1/C17H15NO4/c19-15(20)10-17(22)13-8-4-5-9-14(13)18(16(17)21)11-12-6-2-1-3-7-12/h1-9,22H,10-11H2,(H,19,20)/p-1/t17-/m1/s1

Upstream product

• 28284-05-1 N-benzoylisatin 
• 141-82-2 malonic acid 

Downstream Products

• 500220-02-0 methyl (N-benzyl-3-hydroxy-2-oxindol-3-yl)-acetate 
• 1380340-91-9 C₁₈H₁₇NO₄ 
• 14602-03-0 1-benzyl-3-(2-hydroxyethyl)indole 

Relevant articles and documents

3-Hydroxy-3-((3-methyl-4-nitroisoxazol-5-yl)methyl)indolin-2-one as a versatile intermediate for retro-Henry and Friedel-Crafts alkylation reactions in aqueous medium

The first example of a retro-Henry type reaction is reported using 3-hydroxy-3-((3-methyl-4-nitroisoxazol-5-yl)methyl)indolin-2-ones which are prepared via catalyst-free Henry reaction of 3,5-dimethyl-4-nitroisoxazole and isatin. These compounds were used

A versatile synthetic methodology for the synthesis of tryptophols

Tryptophols have been obtained in high yields by the reduction of 3-substituted-dioxindoles (obtained by the aldol condensation reaction of ketones with isatins or by a modified Knovenagel malonate condensation) using a borane tetrahydrofuran complex. The reported methodology offers distinct advantages over existing methods for the synthesis of these compounds, including consistently greater yields, diastereoselective syntheses and the possibility for the synthesis of a wide range of structurally different tryptophols. The reduction reaction was found to proceed via an intermediate 1,3-diol-oxindole, which was obtained diastereoselectively and, which was subsequently reduced to the corresponding tryptophol.