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L-Cystine-1,1μ-13C2 is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

136743-62-9

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136743-62-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 136743-62-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,7,4 and 3 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 136743-62:
(8*1)+(7*3)+(6*6)+(5*7)+(4*4)+(3*3)+(2*6)+(1*2)=139
139 % 10 = 9
So 136743-62-9 is a valid CAS Registry Number.

136743-62-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name (2S)-2-amino-3-[[(2S)-2-amino-2-hydroxycarbonylethyl]disulfanyl]propanoic acid

1.2 Other means of identification

Product number -
Other names L-Cystine-1,1 inverted exclamation marka-13C2

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:136743-62-9 SDS

136743-62-9Downstream Products

136743-62-9Relevant articles and documents

REAL-TIME MONITORING OF IN VIVO FREE RADICAL SCAVENGERS THROUGH HYPERPOLARIZED N-ACETYL CYSTEINE ISOTOPES

-

Paragraph 0151-0152, (2021/07/24)

A method of diagnosing or monitoring a patient suffering from cancer, the method comprising: administering a pharmaceutical composition comprising an effective amount of an active agent, wherein the active agent is [1-13C] N-acetyl cysteine, a deuterated derivative thereof, a pharmaceutically acceptable salt of any of the foregoing thereof, or a combination thereof, together with a pharmaceutically acceptable carrier to the patient; and diagnosing or monitoring the patient by hyperpolarized 13C-MRI. Also disclosed is a method of synthesizing [1-13C] N-acetyl cysteine or a deuterated derivative thereof.

Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer

Kang, Yun Pyo,Torrente, Laura,Falzone, Aimee,Elkins, Cody M.,Liu, Min,Asara, John M.,Dibble, Christian C.,Denicola, Gina M.

, (2019/08/12)

NRF2 is emerging as a major regulator of cellular metabolism. However, most studies have been performed in cancer cells, where co-occurring mutations and tumor selective pressures complicate the influence of NRF2 on metabolism. Here we use genetically engineered, non-transformed primary murine cells to isolate the most immediate effects of NRF2 on cellular metabolism. We find that NRF2 promotes the accumulation of intracellular cysteine and engages the cysteine homeostatic control mechanism mediated by cysteine dioxygenase 1 (CDO1), which catalyzes the irreversible metabolism of cysteine to cysteine sulfinic acid (CSA). Notably, CDO1 is preferentially silenced by promoter methylation in human non-small cell lung cancers (NSCLC) harboring mutations in KEAP1, the negative regulator of NRF2. CDO1 silencing promotes proliferation of NSCLC by limiting the futile metabolism of cysteine to the wasteful and toxic byproducts CSA and sulfite (SO3 2-), and depletion of cellular NADPH. Thus, CDO1 is a metabolic liability for NSCLC cells with high intracellular cysteine, particularly NRF2/KEAP1 mutant cells.

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