1367695-01-9Relevant articles and documents
Novel RGD peptidomimetics embedding 1,2,3-triazole as central scaffold; Synthesis and αvβ 3 integrin affinity
Ni, Ming Hong,Esposito, Emiliano,Castorina, Massimo,Pozzo, Alma Dal
scheme or table, p. 401 - 405 (2012/06/16)
Ten new RGD (Arginine-Glycine-Aspartic acid) peptidomimetics have been synthesized and screened for their affinity to αvβ 3 integrin receptor. Arginine and Aspartic acid mimetic subunits were connected through 1,2,3-triazole as central scaffold by click chemistry, affording the final products with good yields. Among them, compounds 3f-j exhibited high affinity to the receptor,with IC50 in the low nanomolar range, comparable to that of the reference compound Cilengitide.