136868-52-5Relevant articles and documents
Selective inhibition of factor inhibiting hypoxia-inducible factor
McDonough, Michael A.,McNeill, Luke A.,Tilliet, Melanie,Papamicael, Cyril A.,Chen, Qiu-Yun,Banerji, Biswadip,Hewitson, Kirsty S.,Schofield, Christopher J.
, p. 7680 - 7681 (2005)
A set of four non-heme iron(II) and 2-oxoglutarate-dependent enzymes catalyze the post-translational modification of a transcription factor, hypoxia inducible factor (HIF), that mediates the hypoxic response in animals. Hydroxylation of HIF both causes it
Sarmentosamide, a novel hexadienamide from Thai soil actinomycetes
Kitani, Shigeru,Tomio, Ayako,Srichaisupakit, Akkaraphol,Daduang, Ratama,Intra, Bungonsiri,Panbangred, Watanalai,Oku, Naoya,Igarashi, Yasuhiro,Nihira, Takuya
, p. 226 - 231 (2013)
A new hexadienamide derivative named sarmentosamide (1) was identified from the culture of Streptomyces sp. SBI108 isolated from Thai soil under an herb. The structure was elucidated on the basis of spectroscopic data, and the absolute configuration was determined by chemical degradation.
Novel inhibitors of prolyl 4-hydroxylase. 3. Inhibition by the substrate analogue N-oxaloglycine and its derivatives
Cunliffe,Franklin,Hales,Hill
, p. 2652 - 2658 (2007/10/02)
N-Oxaloglycine (3) is an α-ketoglutarate (1) analogue that is a competitive inhibitor of prolyl 4-hydroxylase (EC 1.14.11.2). A study of the structure-activity relationships of some other oxalo derivatives shows that substitution on the glycine moiety mod