Diastereoselective Claisen Condensation-Type Reactions of Alkyl 2,2-dialkoxycyclopropanecarboxylates with Esters and Acid Chlorides Promoted by Titanium(IV) Chloride
In the presence of titanium(IV) chloride, alkyl 2,2-dialkoxycyclopropanecarboxylates reacted with esters and acid chlorides to give Claisen condensation-type products.The reaction essentially proceeded with extremely high diastereoselectivity.