Benzylic phosphates as electrophiles in the palladium-catalyzed asymmetric benzylation of azlactones
Palladium-catalyzed asymmetric benzylation has been demonstrated with azlactones as prochiral nucleophiles in the presence of chiral bisphosphine ligands. Benzylic electrophiles are utilized under two sets of reaction conditions to construct a new tetrasubstituted stereocenter. Electron density of the phenyl ring dictates the reaction conditions, including the leaving group. The reported methodology represents a novel asymmetric carbon-carbon bond formation in an amino acid precursor.
Trost, Barry M.,Czabaniuk, Lara C.
p. 5778 - 5781
(2012/05/07)
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