1369427-40-6 Usage
Uses
Used in Organic Synthesis:
(2R,3R)-3-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropionic acid dicyclohexylamine salt is used as a synthetic intermediate for the preparation of various complex organic molecules. Its unique structure, including the chiral center and the Boc protecting group, makes it a valuable building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Chemical Research:
In the field of chemical research, (2R,3R)-3-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropionic acid dicyclohexylamine salt serves as a model compound for studying reaction mechanisms, stereochemistry, and the development of new synthetic methodologies. Its complex structure allows researchers to explore innovative approaches to organic synthesis and gain insights into the reactivity of different functional groups.
Used in Pharmaceutical Development:
(2R,3R)-3-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropionic acid dicyclohexylamine salt is used as a precursor in the development of new pharmaceutical agents. Its chiral center and functional groups can be further modified to create potential drug candidates with specific therapeutic properties. (2R,3R)-3-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropionic acid dicyclohexylamine salt's versatility in organic synthesis makes it a promising starting point for the design of novel medications.
Used in Agrochemical Production:
In the agrochemical industry, (2R,3R)-3-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropionic acid dicyclohexylamine salt is utilized as a key intermediate in the synthesis of new pesticides and other crop protection agents. Its unique structural features can be leveraged to create molecules with improved efficacy, selectivity, and environmental compatibility.
Overall, the diverse applications of (2R,3R)-3-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropionic acid dicyclohexylamine salt highlight its importance in various sectors, ranging from organic synthesis to pharmaceutical and agrochemical development. Its complex structure and functional groups make it a valuable asset in the creation of innovative and effective products.
Check Digit Verification of cas no
The CAS Registry Mumber 1369427-40-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,6,9,4,2 and 7 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1369427-40:
(9*1)+(8*3)+(7*6)+(6*9)+(5*4)+(4*2)+(3*7)+(2*4)+(1*0)=186
186 % 10 = 6
So 1369427-40-6 is a valid CAS Registry Number.
1369427-40-6Relevant articles and documents
Process Development and GMP Production of a Conjugate Warhead: Auristatin F-HPA-Ala/TFA (XMT-1864/TFA)
Conlon, Patrick R.,Gurijala, Venu Reddy,Kaufman, Michael,Li, Dachang,Li, Jiuyuan,Li, Yuanyuan,Reddy, Bollu Satyanarayan,Wagler, Thomas,Wang, Zedong,Xu, Zhongmin,Yin, Mao,Yurkovetskiy, Aleksandr V.,Zhu, Lei
, (2022/03/01)
An efficient, large-scale manufacturing process is described for XMT-1864/TFA (1-TFA), an auristatin F derivative, used as a novel, highly potent, cytotoxic warhead in Mersana's oncology antibody-drug conjugate platforms. The process achieves high diastereomeric purity and controls the impurities with all intermediates readily isolated by crystallization or precipitation in high yield and purity. Protecting groups were selected to ensure tolerability, scalability, and stability of the intermediates under various solution-phase peptide coupling conditions. Crystallization of the final product was developed to remove specified impurities and provide a high-purity active warhead molecule for use in the bioconjugation processing. The convergent synthesis involving six non-GMP steps and five GMP steps has been carried out in multiple cGMP productions on 1-kg scale to produce 1-TFA in >98% chemical purity and 1% total diastereomeric contamination with ～50% overall yield for the GMP steps.
Synthesis method of N-Boc-Dolaproine and synthesis method of Boc-Dap DCHA
-
, (2020/07/21)
The invention discloses a synthesis method of N-Boc-Dolaproine and a synthesis method of Boc-Dap DCHA. The synthesis method comprises the following steps: 1) subjecting a compound shown in the specification and a compound shown in the specification to a Reformatsky reaction under the activation of zinc powder to synthesize a compound shown in the specification, with X being Cl or Br or I, and R being alkane or olefin; 2) subjecting the compound shown in the specification to methylation to obtain a compound shown in the specification; 3) carrying out a hydrolysis reaction on the compound shownin the specification so as to obtain N-Boc-Dolaproine. By applying the technical scheme of the invention, the yield of each step of reaction is relatively good, the intermediates are easy to purify, the process route used by the method is relatively short, the material price is relatively low, the synthesis process is simple to operate, the production cost is further reduced, and the methods can be applied to industrial production.
