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136944-37-1

(E)-3-(3,4-Dihydroxyphenoxy)-N-hexylpropenamide is a synthetic chemical compound with the molecular formula C18H23NO4. It is an amide derivative of (E)-3-(3,4-dihydroxyphenoxy)prop-1-ene, containing a hexyl chain. (E)-3-(3,4-Dihydroxyphenoxy)-N-hexylpropenamide is often utilized in research and development as a potential drug candidate for various applications, such as in the treatment of inflammatory and neurodegenerative diseases. Its potential antioxidant and anti-inflammatory properties make it a promising candidate for further pharmaceutical research. Additionally, it may have potential applications in the development of cosmetic and skincare products due to its antioxidant and anti-aging properties.

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  • 136944-37-1 Structure

  • Basic information

    1. Product Name: (E)-3-(3,4-Dihydroxyphenoxy)-N-hexylpropenamide
    2. Synonyms: (E)-3-(3,4-Dihydroxyphenoxy)-N-hexylpropenamide;(E)-N-Hexyl-3-(3,4-dihydroxyphenoxy)propenamide
    3. CAS NO:136944-37-1
    4. Molecular Formula: C15H21NO4
    5. Molecular Weight: 279.33
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 136944-37-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (E)-3-(3,4-Dihydroxyphenoxy)-N-hexylpropenamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: (E)-3-(3,4-Dihydroxyphenoxy)-N-hexylpropenamide(136944-37-1)
    11. EPA Substance Registry System: (E)-3-(3,4-Dihydroxyphenoxy)-N-hexylpropenamide(136944-37-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 136944-37-1(Hazardous Substances Data)

136944-37-1 Usage

Uses

Used in Pharmaceutical Research:
(E)-3-(3,4-Dihydroxyphenoxy)-N-hexylpropenamide is used as a potential drug candidate for the treatment of inflammatory and neurodegenerative diseases. Its application is based on its potential antioxidant and anti-inflammatory properties, which may contribute to the development of novel therapeutics for these conditions.
Used in Cosmetic and Skincare Product Development:
(E)-3-(3,4-Dihydroxyphenoxy)-N-hexylpropenamide is used as an ingredient in the development of cosmetic and skincare products for its antioxidant and anti-aging properties. The application reason is that these properties can help protect the skin from oxidative stress and promote a more youthful appearance, making it a valuable component in the formulation of skincare products.

Check Digit Verification of cas no

The CAS Registry Mumber 136944-37-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,9,4 and 4 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 136944-37:
(8*1)+(7*3)+(6*6)+(5*9)+(4*4)+(3*4)+(2*3)+(1*7)=151
151 % 10 = 1
So 136944-37-1 is a valid CAS Registry Number.

136944-37-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name trans-N-n-Hexyl-β-(3,4-dihydroxyphenoxy)acrylamide

1.2 Other means of identification

Product number -
Other names (E)-3-(3,4-Dihydroxy-phenoxy)-N-hexyl-acrylamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:136944-37-1 SDS

136944-37-1Downstream Products

136944-37-1Relevant articles and documents

Quantitative structure-activity relationship of catechol derivatives inhibiting 5-lipoxygenase

Naito,Sugiura,Yamaura,Fukaya,Yokoyama,Nakagawa,Ikeda,Senda,Fujita

, p. 1736 - 1745 (2007/10/02)

Various catechol derivatives (β-substituted 3,4-dihydroxystyrenes, 1-substituted 3,4-dihydroxybenzenes, and 6-substituted 2,3-dihydroxynaphthalenes) were synthesized and their inhibition of 5-lipoxygenase was assayed. Their structure-activity relationships were examined quantitatively with substituent and structural parameters and regression analysis. The variations in the inhibitory activity were explained in bilinear hydrophobic parameter (log P) terms, and steric (molecular thickness) and electronic (proton nuclear magnetic resonance (1H-NMR) chemical shift of the proton adjacent to the catechol group) parameter terms. The hydrophobicity of the inhibitor molecule was important, and the optimum value of log P was about 4.3-4.6, beyond which inhibition did not increase further. A low electron density of the aromatic ring containing the catechol group and the greater thickness of the lipophilic side chains were unfavorable to the activity. The results added a physicochemical basis for the selection of candidate compounds for developmental studies.

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