Thymidine phosphorylase and prostrate cancer cell proliferation inhibitory activities of synthetic 4-hydroxybenzohydrazides: In vitro, kinetic, and in silico studies
Over-expression of thymidine phosphorylase (TP) plays a key role in many pathological complications, including angiogenesis which leads to cancer cells proliferation. Thus in search of new anticancer agents, a series of 4-hydroxybenzohydrazides (1–29) was
Cobalt(III) complexes with tridentate hydrazone ligands: Protonation state and hydrogen bond competition
Cobalt(iii) complexes of the type [Co(HL)(L)] were synthesized under solvothermal conditions staring from [Co(C5H7O2)3] and the corresponding ligand H2L (salicylaldehyde 4-hydroxybenzhydrazone, 3-meth
Design, synthesis and in vitro antimalarial activity of an acylhydrazone library
A library of acylhydrazone iron chelators was synthesized and tested for its ability to inhibit the growth of a chloroquine-resistant strain of Plasmodium falciparum. Some of these new compounds are significantly more active than desferrioxamine DFO, the
Melnyk, Patricia,Leroux, Virginie,Sergheraert, Christian,Grellier, Philippe
p. 31 - 35
(2007/10/03)
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