- Bulladecin and atemotetrolin, two bis-tetrahydrofuran acetogenins from Annona atemoya seeds
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Two new C37 tetrahydroxy adjacent bis-tetrahydrofuran acetogenins with a vicinal diol, bulladecin and atemotetrolin, were isolated from the methanol extract of Annona atemoya seeds and characterized by spectroscopic techniques. In addition the known compounds, cherimolin-2 and almunequin, were isolated and identified.
- Duret, Philippe,Hocquemiller, Reynald,Cave, Andre
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- γ-lactone-functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I
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To study the relevance of the terminal α,β-unsaturated γ-methyl-γ-lactone moiety of the antitumoral acetogenins of Annonaceae for potent mitochondrial complex I inhibition, we have prepared a series of semisynthetic acetogenins with modifications only in this part of the molecule, from the natural rolliniastatin-1 (1) and cherimolin-1 (2). Some of the hydroxylated derivatives (1b, 1d and 1e) in addition to two infrequent natural β-hydroxy γ-methyl γ-lactone acetogenins, laherradurin (3) and itrabin (4), are more potent complex I inhibitors than any other known compounds.
- Tormo, Jose R,Estornell, Ernesto,Gallardo, Teresa,Gonzalez,Cave, Adrien,Granell, Susana,Cortes, Diego,Zafra-Polo
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