137069-25-1 Usage
Uses
Used in Organic Synthesis:
N-Methyl-4-(trifluoromethyl)-benzeneethanamine is utilized as a key intermediate in organic synthesis for the production of various chemical compounds. Its unique structure and properties make it a valuable component in the synthesis of complex organic molecules.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, N-Methyl-4-(trifluoromethyl)-benzeneethanamine is employed as a precursor in the development of pharmaceuticals. Its ability to be modified and incorporated into different molecular frameworks allows for the creation of novel drug candidates with potential therapeutic applications.
Used in Pharmaceutical Development:
N-Methyl-4-(trifluoromethyl)-benzeneethanamine is used as a building block in the design and synthesis of new pharmaceuticals. Its presence in the molecular structure can impart specific biological activities, making it an essential component in the development of innovative treatments for various diseases and conditions.
Used in Chemical Research:
N-Methyl-4-(trifluoroMethyl)-benzeneethanaMine is also utilized in chemical research to explore its reactivity, stability, and potential applications in various chemical reactions. Understanding its properties and behavior can contribute to the advancement of chemical knowledge and the discovery of new synthetic pathways.
Used in Specialty Chemicals Production:
N-Methyl-4-(trifluoromethyl)-benzeneethanamine is employed in the production of specialty chemicals, where its unique properties can be leveraged to create high-value products for specific industries, such as agrochemicals, materials science, and fragrances.
Check Digit Verification of cas no
The CAS Registry Mumber 137069-25-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,7,0,6 and 9 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 137069-25:
(8*1)+(7*3)+(6*7)+(5*0)+(4*6)+(3*9)+(2*2)+(1*5)=131
131 % 10 = 1
So 137069-25-1 is a valid CAS Registry Number.
137069-25-1Relevant articles and documents
Structure-Activity Relationship Studies of Pyrimidine-4-Carboxamides as Inhibitors of N-Acylphosphatidylethanolamine Phospholipase D
Mock, Elliot D.,Kotsogianni, Ioli,Driever, Wouter P. F.,Fonseca, Carmen S.,Vooijs, Jelle M.,Den Dulk, Hans,Van Boeckel, Constant A. A.,Van Der Stelt, Mario
, p. 481 - 515 (2021/02/05)
N-Acylphosphatidylethanolamine phospholipase D (NAPE-PLD) is regarded as the main enzyme responsible for the biosynthesis of N-acylethanolamines (NAEs), a family of bioactive lipid mediators. Previously, we reported N-(cyclopropylmethyl)-6-((S)-3-hydroxypyrrolidin-1-yl)-2-((S)-3-phenylpiperidin-1-yl)pyrimidine-4-carboxamide (1, LEI-401) as the first potent and selective NAPE-PLD inhibitor that decreased NAEs in the brains of freely moving mice and modulated emotional behavior [ Mock et al. Nat Chem. Biol., 2020, 16, 667-675 ]. Here, we describe the structure-activity relationship (SAR) of a library of pyrimidine-4-carboxamides as inhibitors of NAPE-PLD that led to the identification of LEI-401. A high-throughput screening hit was modified at three different substituents to optimize its potency and lipophilicity. Conformational restriction of an N-methylphenethylamine group by replacement with an (S)-3-phenylpiperidine increased the inhibitory potency 3-fold. Exchange of a morpholine substituent for an (S)-3-hydroxypyrrolidine reduced the lipophilicity and further increased activity by 10-fold, affording LEI-401 as a nanomolar potent inhibitor with drug-like properties. LEI-401 is a suitable pharmacological tool compound to investigate NAPE-PLD function in vitro and in vivo.
INHIBITORS OF N-ACYLPHOSPHATIDYLETHANOLAMINE PHOSPHOLIPASE D (NAPE-PLD)
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, (2019/12/15)
The invention relates to a compound of the formula (I) as novel inhibitor of N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD), and to use thereof for the prophylaxis or treatment of diseases associated with NAPE-PLD. wherein in a ring A, X1 is N, or CR4; X2 is N or CR5; X3 is N or CH; with the proviso that at least one of X1 and X3 is N.
