An in Situ Approach to Nickel-Catalyzed Cycloaddition of Alkynes and 3-Azetidinones
An efficient and convenient procedure that generates the active Ni(0) catalyst in situ from cheap, air stable Ni(II) precursors is developed for the [4 + 2]-cycloaddition of alkynes and 3-azetidinones. The reaction affords useful 3-dehydropiperidinones in
Described herein are methods for synthesizing substituted 3-piperidone compounds. Notably, substituted 3-piperidones can also be prepared in enantiopure form. The methods may allow for preparation of highly substituted piperidine cores. Also disclosed are
-
Paragraph 0160; 0162-0163
(2013/03/26)
A single step approach to piperidines via ni-catalyzed β-carbon elimination
An easy and expeditious route to substituted piperidines is described. A Ni-phosphine complex was used as catalyst for [4 + 2] cycloaddition of 3-azetidinone and alkynes. The reaction has broad substrate scope and affords piperidines in excellent yields a
Kumar, Puneet,Louie, Janis
supporting information; experimental part
p. 2026 - 2029
(2012/06/29)
More Articles about upstream products of 1372173-47-1