Ester as a blocking group for palladium-catalysed direct forced arylation at the unfavourable site of heteroaromatics: Simple access to the less accessible regioisomers
The use of esters as blocking groups at the C2 position on a range of 3-substituted 5-membered ring heteroaromatics such as thiophenes or furans, allows control of the regioselectivity for the palladium-catalysed direct arylation at C5-H. This arylation can be followed by easy decarboxylation. This method allows sequential catalytic C5 arylation, decarboxylation and catalytic C2 arylation reactions.
Chen, Lu,Bruneau, Christian,Dixneuf, Pierre H.,Doucet, Henri
experimental part
p. 1111 - 1124
(2012/06/18)
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