Chlorostyrenes in iron-catalyzed biaryl coupling reactions
An effective protocol for iron-catalyzed biaryl syntheses by coupling chlorostyrenes with aryl Grignard reagents requires only mild reaction conditions and tolerates various functional groups. The underlying activation of deactivated aryl chlorides proceeds through a rate-determining coordination of the catalyst to the vinyl substituent and subsequent haptotropic migration along the conjugated πsystem to the site of C-Cl bond cleavage. Copyright
Guelak, Samet,Jacobivonwangelin, Axel
p. 1357 - 1361
(2012/03/26)
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