Stereoselective Radical-Mediated Cyclization of Norephedrine Derived α-Iodoamides: Synthesis of Enantiopure Pyrrolidines and Transition State Modelling
Radical-mediated cyclization of norephedrine derived α-iodoamides 1 was found to be highly stereoselective ( 97:3) favouring diastereoisomer 2.Bicyclic lactams 2 were transformed in high yields into enantiomerically pure pyrrolidines 10.Transition stat
Belvisi, Laura,Gennari, Cesare,Poli, Giovanni,Scolastico, Carlo,Salom, Barbara,Vassallo, Marco
p. 3945 - 3960
(2007/10/02)
Stereoselective Radical-Mediated Cyclization of Norephedrine Derived α-Iodoamides: Experiments and TS-Modelling
Radical-mediated cyclization of norephedrine derived α-iodoamides 1 was found to be highly stereoselective (97:3) favouring diastereoisomer 2.Transition state modelling with a force field developed ad hoc, nicely predicts the stereochemical results.
Gennari, Cesare,Poli, Giovanni,Scolastico, Carlo,Vassallo, Marco
p. 793 - 796
(2007/10/02)
More Articles about upstream products of 137314-81-9